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Lypd6b Gene Detail
Summary
  • Symbol
    Lypd6b
  • Name
    LY6/PLAUR domain containing 6B
  • Synonyms
    2310010M24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919147
    NCBI Gene: 71897
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:49677700-49838861 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 28.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5022 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919147
 protein coding gene Chr2:49677380-49838861 (+)
129S1/SvImJ ENSMUSG00200010194
 protein coding gene Chr2:46653014-46814302 (+)
A/J ENSMUSG00195010079
 protein coding gene Chr2:46794744-46956412 (+)
AKR/J ENSMUSG00220020074
 protein coding gene Chr2:46926422-47088103 (+)
BALB/cJ ENSMUSG00180021126
 protein coding gene Chr2:46787681-46949314 (+)
C3H/HeJ ENSMUSG00175012759
 protein coding gene Chr2:46819048-46980694 (+)
C57BL/6NJ ENSMUSG00215008957
 protein coding gene Chr2:46833320-46994978 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023547
 protein coding gene Chr2:45161633-45320723 (+)
CAST/EiJ ENSTCUG00005001261
 protein coding gene Chr2:46374067-46537002 (+)
CBA/J ENSMUSG00210000958
 protein coding gene Chr2:46832347-46993984 (+)
DBA/2J ENSMUSG00185002331
 protein coding gene Chr2:46692512-46854163 (+)
FVB/NJ ENSMUSG00205001704
 protein coding gene Chr2:46462888-46654129 (+)
JF1/MsJ ENSUMUG00000000534
 protein coding gene Chr2:46509138-46671758 (+)
LP/J ENSMUSG00230000713
 protein coding gene Chr2:48617275-48774719 (+)
NOD/ShiLtJ ENSMUSG00190001491
 protein coding gene Chr2:46747628-46909260 (+)
NZO/HlLtJ ENSMUSG00225000492
 protein coding gene Chr2:56323526-56485197 (+)
PWK/PhJ ENSLUMG00010004262
 protein coding gene Chr2:46683838-46845434 (+)
SPRET/EiJ ENSMSPG00010010440
 protein coding gene Chr2:47682674-47791284 (+)
WSB/EiJ ENSIUOG00005001178
 protein coding gene Chr2:46779742-46941180 (+)



Homology
more
  • Human Ortholog
    LYPD6B, LY6/PLAUR domain containing 6B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LYPD6B, LY6/PLAUR domain containing 6B
  • Synonyms
    CT116, LYPD7
  • Links
    NCBI Gene ID: 130576
    UniProt: Q8NI32

  • Chr Location
    2q23.2; chr2:149037975-149215262 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    666
  • Tissues
    25
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026765 Ensembl Gene Model | MGI Sequence Detail 161162 C57BL/6J ±  kb
    transcript ENSMUST00000028103 Ensembl | MGI Sequence Detail 2286 Not Applicable  
    polypeptide ENSMUSP00000028103 Ensembl | MGI Sequence Detail 172 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139280
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:378404 Liu T, et al., Lypd6b depletion promotes CD8(+) T cell-mediated anti-tumor immunity via metabolic reprogramming in colorectal cancer. Nat Commun. 2025 Dec 11;17(1):675
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory