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Slc25a18 Gene Detail
Summary
  • Symbol
    Slc25a18
  • Name
    solute carrier family 25 (mitochondrial carrier), member 18
  • Synonyms
    1500015I14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919053
    NCBI Gene: 71803
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:120750539-120771297 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 57.00 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    191 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919053
 protein coding gene Chr6:120750527-120771297 (+)
129S1/SvImJ ENSMUSG00200050694
 protein coding gene Chr6:117952002-117972532 (+)
A/J ENSMUSG00195045528
 protein coding gene Chr6:117366133-117386664 (+)
AKR/J ENSMUSG00220022100
 protein coding gene Chr6:116251358-116271897 (+)
BALB/cJ ENSMUSG00180036603
 protein coding gene Chr6:117733787-117754318 (+)
C3H/HeJ ENSMUSG00175038475
 protein coding gene Chr6:59716007-59736534 (-)
C57BL/6NJ ENSMUSG00215046128
 protein coding gene Chr6:117717912-117738679 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028806
 protein coding gene Chr6:115828892-115850289 (+)
CAST/EiJ ENSTCUG00005049008
 protein coding gene Chr6:117531113-117551515 (+)
CBA/J ENSMUSG00210044074
 protein coding gene Chr6:117500781-117521305 (+)
DBA/2J ENSMUSG00185046758
 protein coding gene Chr6:118156175-118176941 (+)
FVB/NJ ENSMUSG00205036813
 protein coding gene Chr6:116597988-116618761 (+)
JF1/MsJ ENSUMUG00000052628
 protein coding gene Chr6:116758064-116777737 (+)
LP/J ENSMUSG00230039625
 protein coding gene Chr6:119349371-119369900 (+)
NOD/ShiLtJ ENSMUSG00190025856
 protein coding gene Chr6:117113692-117134219 (+)
NZO/HlLtJ ENSMUSG00225047448
 protein coding gene Chr6:121241687-121262455 (+)
PWK/PhJ ENSLUMG00010044681
 protein coding gene Chr6:116102690-116122388 (+)
SPRET/EiJ ENSMSPG00010037634
 protein coding gene Chr6:118971542-118991876 (+)
WSB/EiJ ENSIUOG00005040047
 protein coding gene Chr6:117758666-117779437 (+)



Homology
more
  • Human Ortholog
    SLC25A18, solute carrier family 25 member 18
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC25A18, solute carrier family 25 member 18
  • Synonyms
    GC2
  • Links
    NCBI Gene ID: 83733
    UniProt: Q9H1K4

  • Chr Location
    22q11.21; chr22:17563086-17591909 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    11
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004902 Ensembl Gene Model | MGI Sequence Detail 20759 C57BL/6J ±  kb
    transcript ENSMUST00000112682 Ensembl | MGI Sequence Detail 1911 Not Applicable  
    polypeptide ENSMUSP00000108302 Ensembl | MGI Sequence Detail 320 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000015013 mitochondrial glutamate carrier 2
      (term hierarchy)
    • InterPro Domains
      IPR002067 Mitochondrial carrier protein
      IPR023395 Mitochondrial carrier protein domain superfamily
      IPR018108 Mitochondrial carrier protein, transmembrane region
      IPR051028 Mitochondrial Solute Carrier
    • GlyGen
      Q9DB41 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141654
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:387856 Murlanova K, et al., NPAS3-regulated astrocyte mitochondrial bioenergetics is required for cognition. Sci Adv. 2026 Jun 19;12(25):eadt2527
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory