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Tspan33 Gene Detail
Summary
  • Symbol
    Tspan33
  • Name
    tetraspanin 33
  • Synonyms
    1300010A20Rik, Pen, Penumbra
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919012
    NCBI Gene: 232670
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:29694221-29718558 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 12.36 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    700 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919012
 protein coding gene Chr6:29694213-29718558 (+)
129S1/SvImJ ENSMUSG00200032561
 protein coding gene Chr6:26749733-26774067 (+)
A/J ENSMUSG00195008229
 protein coding gene Chr6:26712254-26736595 (+)
AKR/J ENSMUSG00220003617
 protein coding gene Chr6:26305325-26329667 (+)
BALB/cJ ENSMUSG00180019196
 protein coding gene Chr6:26843913-26868257 (+)
C3H/HeJ ENSMUSG00175018371
 protein coding gene Chr6:26707165-26731511 (+)
C57BL/6NJ ENSMUSG00215014711
 protein coding gene Chr6:26734489-26758834 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028177
 protein coding gene Chr6:24550459-24574030 (+)
CAST/EiJ ENSTCUG00005026024
 protein coding gene Chr6:26286405-26310737 (+)
CBA/J ENSMUSG00210003457
 protein coding gene Chr6:26728442-26752776 (+)
DBA/2J ENSMUSG00185019462
 protein coding gene Chr6:26822962-26847292 (+)
FVB/NJ ENSMUSG00205031135
 protein coding gene Chr6:26797384-26821720 (+)
JF1/MsJ ENSUMUG00000014858
 protein coding gene Chr6:26506975-26531557 (+)
LP/J ENSMUSG00230026596
 protein coding gene Chr6:27766364-27790690 (+)
NOD/ShiLtJ ENSMUSG00190024987
 protein coding gene Chr6:26591985-26616318 (+)
NZO/HlLtJ ENSMUSG00225014291
 protein coding gene Chr6:29727343-29751681 (+)
PWK/PhJ ENSLUMG00010024036
 protein coding gene Chr6:26293350-26317867 (+)
SPRET/EiJ ENSMSPG00010020476
 protein coding gene Chr6:26724138-26748121 (+)
WSB/EiJ ENSIUOG00005030567
 protein coding gene Chr6:26894396-26918723 (+)



Homology
more
  • Human Ortholog
    TSPAN33, tetraspanin 33
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSPAN33, tetraspanin 33
  • Synonyms
    PEN, PEN., TSPAN-33
  • Links
    NCBI Gene ID: 340348
    UniProt: Q86UF1

  • Chr Location
    7q32.1; chr7:129144690-129169699 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display anemia and partial penetrance of red blood cell abnormalities, splenomegaly, monocytosis, thrombocytopenia, reticulocytosis, and extramedullary hematopoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    624
  • Tissues
    4
  • cDNA Data
    30
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001763 Ensembl Gene Model | MGI Sequence Detail 24338 C57BL/6J ±  kb
    transcript ENSMUST00000046750 Ensembl | MGI Sequence Detail 1994 Not Applicable  
    polypeptide ENSMUSP00000045282 Ensembl | MGI Sequence Detail 283 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 30

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2144063
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:376291 Kang M, et al., Latrophilin-2 Deletion in Cardiomyocyte Disrupts Cell Junction, Leading to D-CMP. Circ Res. 2024 Nov 8;135(11):1098-1115
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory