About   Help   FAQ
Derl3 Gene Detail
Summary
  • Symbol
    Derl3
  • Name
    Der1-like domain family, member 3
  • Synonyms
    1810006I20Rik, 1810063P04Rik, derlin-3, IZP6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917627
    NCBI Gene: 70377
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:75729247-75731775 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 38.61 cM, cytoband B5.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    123 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917627
 protein coding gene Chr10:75729232-75731775 (+)
129S1/SvImJ ENSMUSG00200045808
 protein coding gene Chr10:72430758-72433286 (+)
A/J ENSMUSG00195047567
 protein coding gene Chr10:72742899-72745427 (+)
AKR/J ENSMUSG00220043700
 protein coding gene Chr10:72402637-72405165 (+)
BALB/cJ ENSMUSG00180052752
 protein coding gene Chr10:72757364-72759892 (+)
C3H/HeJ ENSMUSG00175041723
 protein coding gene Chr10:72628693-72631221 (+)
C57BL/6NJ ENSMUSG00215051536
 protein coding gene Chr10:72366286-72368814 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015454
 protein coding gene Chr10:69928148-69930678 (+)
CAST/EiJ ENSTCUG00005048587
 protein coding gene Chr10:72241882-72244410 (+)
CBA/J ENSMUSG00210043513
 protein coding gene Chr10:72484868-72487396 (+)
DBA/2J ENSMUSG00185050411
 protein coding gene Chr10:72827153-72829681 (+)
FVB/NJ ENSMUSG00205026404
 protein coding gene Chr10:72520177-72522705 (+)
JF1/MsJ ENSUMUG00000054461
 protein coding gene Chr10:73968636-73971149 (+)
LP/J ENSMUSG00230047827
 protein coding gene Chr10:74596749-74599277 (+)
NOD/ShiLtJ ENSMUSG00190046757
 protein coding gene Chr10:72804681-72807209 (+)
NZO/HlLtJ ENSMUSG00225045755
 protein coding gene Chr10:78893229-78895757 (+)
PWK/PhJ ENSLUMG00010048991
 protein coding gene Chr10:72363520-72366032 (+)
SPRET/EiJ ENSMSPG00010047257
 protein coding gene Chr10:74164476-74167000 (+)
WSB/EiJ ENSIUOG00005047471
 protein coding gene Chr10:72393208-72395727 (+)



Homology
more
  • Human Ortholog
    DERL3, derlin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DERL3, derlin 3
  • Synonyms
    C22orf14, derlin-3, IZP6, LLN2
  • Links
    NCBI Gene ID: 91319
    UniProt: Q96Q80

  • Chr Location
    22q11.23; chr22:23834503-23839128 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Mice homozygous for this gene trapped allele show no obvious phenotype alterations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    655
  • Tissues
    45
  • cDNA Data
    47
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000009092 Ensembl Gene Model | MGI Sequence Detail 2529 C57BL/6J ±  kb
transcript ENSMUST00000009236 Ensembl | MGI Sequence Detail 1321 Not Applicable  
polypeptide ENSMUSP00000009236 Ensembl | MGI Sequence Detail 228 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 49
    cDNA 47
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1916287
References
more
  • Summaries
    All 44
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory