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Ube3d Gene Detail
Summary
  • Symbol
    Ube3d
  • Name
    ubiquitin protein ligase E3D
  • Synonyms
    2610018I03Rik, Ube2cbp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917598
    NCBI Gene: 70348
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:86189364-86347003 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 46.58 cM, cytoband E3.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4874 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917598
 protein coding gene Chr9:86189359-86347003 (-)
129S1/SvImJ ENSMUSG00200005297
 protein coding gene Chr9:83295580-83471194 (-)
A/J ENSMUSG00195007128
 protein coding gene Chr9:83083390-83246631 (-)
AKR/J ENSMUSG00220019338
 protein coding gene Chr9:83222237-83379958 (-)
BALB/cJ ENSMUSG00180006770
 protein coding gene Chr9:83188293-83351535 (-)
C3H/HeJ ENSMUSG00175004641
 protein coding gene Chr9:83248362-83411592 (-)
C57BL/6NJ ENSMUSG00215006557
 protein coding gene Chr9:83196120-83353777 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032494
 protein coding gene Chr9:82864146-83014671 (-)
CAST/EiJ ENSTCUG00005003785
 protein coding gene Chr9:82784089-82942566 (-)
CBA/J ENSMUSG00210005703
 protein coding gene Chr9:83314799-83472442 (-)
DBA/2J ENSMUSG00185001451
 protein coding gene Chr9:83330532-83481440 (-)
FVB/NJ ENSMUSG00205004326
 protein coding gene Chr9:83500081-83663255 (-)
JF1/MsJ ENSUMUG00000016175
 protein coding gene Chr9:83194016-83350318 (-)
LP/J ENSMUSG00230009105
 protein coding gene Chr9:83444194-83604899 (-)
NOD/ShiLtJ ENSMUSG00190010856
 protein coding gene Chr9:83392019-83549736 (-)
NZO/HlLtJ ENSMUSG00225015480
 protein coding gene Chr9:83631436-83785195 (-)
PWK/PhJ ENSLUMG00010002598
 protein coding gene Chr9:83131801-83288756 (-)
SPRET/EiJ ENSMSPG00010002423
 protein coding gene Chr9:84578675-84739714 (-)
WSB/EiJ ENSIUOG00005003435
 protein coding gene Chr9:82796553-82946550 (-)



Homology
more
  • Human Ortholog
    UBE3D, ubiquitin protein ligase E3D
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBE3D, ubiquitin protein ligase E3D
  • Synonyms
    C6orf157, H10BH, UBE2CBP, YJR141W
  • Links
    NCBI Gene ID: 90025
    UniProt: Q7Z6J8

  • Chr Location
    6q14.1; chr6:82880802-83065841 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele cannot be obtained. Heterozygotes exhibit abnormal retinal pigment epithelium morphology and decreased a- and b-wave amplitude.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70348 NCBI Gene Model | MGI Sequence Detail 157640 C57BL/6J ±  kb
    transcript NM_027394 RefSeq | MGI Sequence Detail 1785 C57BL/6  
    polypeptide Q8BX13 UniProt | EBI | MGI Sequence Detail 368 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:7482307
    References
    more
    • Summaries
      All 36
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:343194 Tao T, et al., Conditional loss of Ube3d in the retinal pigment epithelium accelerates age-associated alterations in the retina of mice. J Pathol. 2023 Dec;261(4):442-454
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory