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Tprkb Gene Detail
Summary
  • Symbol
    Tprkb
  • Name
    Tp53rk binding protein
  • Synonyms
    0610033G21Rik, 1810034M08Rik, DRWMS1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917036
    NCBI Gene: 69786
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:85888847-85907266 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.53 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    412 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917036
 protein coding gene Chr6:85888842-85907266 (+)
129S1/SvImJ ENSMUSG00200041443
 protein coding gene Chr6:82834070-82864067 (+)
A/J ENSMUSG00195037985
 protein coding gene Chr6:82518375-82548372 (+)
AKR/J ENSMUSG00220028140
 protein coding gene Chr6:81428933-81458886 (+)
BALB/cJ ENSMUSG00180014902
 protein coding gene Chr6:82903764-82933717 (+)
C3H/HeJ ENSMUSG00175037088
 protein coding gene Chr6:94480961-94510958 (-)
C57BL/6NJ ENSMUSG00215021576
 protein coding gene Chr6:82899159-82929110 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028587
 protein coding gene Chr6:81925399-81978421 (+)
CAST/EiJ ENSTCUG00005017397
 protein coding gene Chr6:82829151-82864987 (+)
CBA/J ENSMUSG00210035073
 protein coding gene Chr6:82709556-82739553 (+)
DBA/2J ENSMUSG00185043048
 protein coding gene Chr6:83256700-83286697 (+)
FVB/NJ ENSMUSG00205038790
 protein coding gene Chr6:81887568-81917565 (+)
JF1/MsJ ENSUMUG00000028742
 protein coding gene Chr6:82197140-82232280 (+)
LP/J ENSMUSG00230044524
 protein coding gene Chr6:84390717-84420714 (+)
NOD/ShiLtJ ENSMUSG00190042226
 protein coding gene Chr6:82333322-82363319 (+)
NZO/HlLtJ ENSMUSG00225019101
 protein coding gene Chr6:86354525-86384523 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010031622
 protein coding gene Chr6:83784483-83800452 (+)
WSB/EiJ ENSIUOG00005030946
 protein coding gene Chr6:83238634-83268587 (+)



Homology
more
  • Human Ortholog
    TPRKB, TP53RK binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TPRKB, TP53RK binding protein
  • Synonyms
    CGI-121, CGI121, GAMOS5
  • Links
    NCBI Gene ID: 51002
    UniProt: Q9Y3C4

  • Chr Location
    2p13.1; chr2:73729104-73737421 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TPRKB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die prior to E7.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    61
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054226 Ensembl Gene Model | MGI Sequence Detail 18420 C57BL/6J ±  kb
transcript ENSMUST00000200680 Ensembl | MGI Sequence Detail 814 Not Applicable  
polypeptide ENSMUSP00000144160 Ensembl | MGI Sequence Detail 175 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 61
    cDNA 61

    Microarray probesets 6
Other
Accession IDs
less
MGI:1922059
References
more
  • Summaries
    All 45
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory