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Esam Gene Detail
Summary
  • Symbol
    Esam
  • Name
    endothelial cell-specific adhesion molecule
  • Synonyms
    2310008D05Rik, W117m
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916774
    NCBI Gene: 69524
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:37439385-37449615 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 20.77 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    331 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916774
 protein coding gene Chr9:37439374-37449615 (+)
129S1/SvImJ ENSMUSG00200039086
 protein coding gene Chr9:34426534-34436744 (+)
A/J ENSMUSG00195046790
 protein coding gene Chr9:34213158-34223368 (+)
AKR/J ENSMUSG00220041228
 protein coding gene Chr9:34289368-34299593 (+)
BALB/cJ ENSMUSG00180044559
 protein coding gene Chr9:34341519-34351723 (+)
C3H/HeJ ENSMUSG00175046347
 protein coding gene Chr9:34342511-34352716 (+)
C57BL/6NJ ENSMUSG00215032707
 protein coding gene Chr9:34345245-34355495 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031984
 protein coding gene Chr9:33676052-33686375 (+)
CAST/EiJ ENSTCUG00005042881
 protein coding gene Chr9:34292407-34302736 (+)
CBA/J ENSMUSG00210044512
 protein coding gene Chr9:34324522-34334763 (+)
DBA/2J ENSMUSG00185031736
 protein coding gene Chr9:34438782-34448995 (+)
FVB/NJ ENSMUSG00205024981
 protein coding gene Chr9:34704361-34714805 (+)
JF1/MsJ ENSUMUG00000020313
 protein coding gene Chr9:34529578-34539884 (+)
LP/J ENSMUSG00230028803
 protein coding gene Chr9:34787224-34797523 (+)
NOD/ShiLtJ ENSMUSG00190028838
 protein coding gene Chr9:34457165-34467420 (+)
NZO/HlLtJ ENSMUSG00225018659
 protein coding gene Chr9:34755665-34765954 (+)
PWK/PhJ ENSLUMG00010044937
 protein coding gene Chr9:34471134-34481424 (+)
SPRET/EiJ ENSMSPG00010030484
 protein coding gene Chr9:35029579-35039777 (+)
WSB/EiJ ENSIUOG00005036596
 protein coding gene Chr9:33964157-33974387 (+)



Homology
more
  • Human Ortholog
    ESAM, endothelial cell adhesion molecule
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ESAM, endothelial cell adhesion molecule
  • Synonyms
    NEDIHSS, W117m
  • Links
    NCBI Gene ID: 90952
    UniProt: Q96AP7

  • Chr Location
    11q24.2; chr11:124752583-124762315 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhbit a decrease in body weight, impaired neutrophil transmigration and decreased immune and VEGF-stimulated vascular permeability. Tumor growth is inhibited due to decreased pathological angiogenesis in homozygous mutant mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    675
  • Tissues
    39
  • cDNA Data
    56
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69524 NCBI Gene Model | MGI Sequence Detail 10231 C57BL/6J ±  kb
    transcript NR_136939 RefSeq | MGI Sequence Detail 1870 C57BL/6  
    polypeptide Q925F2 UniProt | EBI | MGI Sequence Detail 394 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 56
      Primer pair 1
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 9
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:64925 Chretien I, et al., CTX, a Xenopus thymocyte receptor, defines a molecular family conserved throughout vertebrates. Eur J Immunol. 1998 Dec;28(12):4094-104
    • Latest
      J:361822 Buncha V, et al., Endothelial cell-selective adhesion molecule deficiency exhibits increased pulmonary vascular resistance due to impaired endothelial nitric oxide signaling. Am J Physiol Heart Circ Physiol. 2025 Feb 1;328(2):H283-H293
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory