Snhg12 MGI Mouse Gene Detail - MGI:1916721 - small nucleolar RNA host gene 12

Symbol

Snhg12
Name

small nucleolar RNA host gene 12
Synonyms

2310005L22Rik

Feature Type

lncRNA gene
IDs

MGI:1916721
NCBI Gene: 100039864
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr4:132035989-132038335 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 65.16 cM
Mapping Data

2 experiments

SNPs within 2kb

207 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916721	lncRNA gene	Chr4:132035905-132038762 (+)
129S1/SvImJ	ENSMUSG00200021672	lncRNA gene	Chr4:125490776-125493624 (+)
A/J	ENSMUSG00195044657	lncRNA gene	Chr4:126815032-126817862 (+)
AKR/J	ENSMUSG00220048487	lncRNA gene	Chr4:125806785-125809615 (+)
BALB/cJ	ENSMUSG00180049388	lncRNA gene	Chr4:124448792-124451623 (+)
C3H/HeJ	ENSMUSG00175049167	lncRNA gene	Chr4:125461189-125464019 (+)
C57BL/6NJ	ENSMUSG00215052225	lncRNA gene	Chr4:126965095-126967924 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0005939	lincRNA gene	Chr4:121941519-121943932 (+)
CAST/EiJ	ENSTCUG00005048867	lncRNA gene	Chr4:126363692-126366502 (+)
CBA/J	ENSMUSG00210054030	lncRNA gene	Chr4:125090151-125092981 (+)
DBA/2J	ENSMUSG00185052729	lncRNA gene	Chr4:126622556-126625386 (+)
FVB/NJ	ENSMUSG00205047999	lncRNA gene	Chr4:124863787-124866740 (+)
JF1/MsJ	ENSUMUG00000047796	lncRNA gene	Chr4:127288971-127291782 (+)
LP/J	ENSMUSG00230038910	lncRNA gene	Chr4:130429259-130432107 (+)
NOD/ShiLtJ	ENSMUSG00190048317	lncRNA gene	Chr4:124854868-124857698 (+)
NZO/HlLtJ	ENSMUSG00225026682	lncRNA gene	Chr4:136333171-136336001 (+)
PWK/PhJ	ENSLUMG00010051291	lncRNA gene	Chr4:124308019-124310849 (+)
SPRET/EiJ	ENSMSPG00010045953	lncRNA gene	Chr4:126381426-126384085 (+)
WSB/EiJ	ENSIUOG00005044327	lncRNA gene	Chr4:124744543-124747370 (+)

Human Ortholog

SNHG12, small nucleolar RNA host gene 12

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SNHG12, small nucleolar RNA host gene 12
Synonyms

ASLNC04080, C1orf79, LINC00100, LINC001000, NCRNA00100, PNAS-123
Links

HGNC:30062

NCBI Gene ID: 85028
Chr Location

1p35.3; chr1:28578536-28583132 (-) GRCh38

MGI Vertebrate Homology

Snhg12 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: SNHG12
Gene Tree

Snhg12

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

119
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

113
Radiation induced

1
Targeted

2
Genomic Mutations

4 involving Snhg12
Find Mice (IMSR)

10 strains or lines available

Mice with endothelium-specific deletion exhibit blood brain barrier and blood retina barrier disruption and impaired memory that are aggravated under hypoxic conditions and reduced neurons in the cortex and hippocampus.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

3

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

75
RefSeq

1

Ensembl

ENSMUSG00000086290 (Evidence)
NCBI Gene

100039864

Representative Sequences				Length	Strain/Species	Flank
	genomic	100039864	NCBI Gene Model \| MGI Sequence Detail	2347	C57BL/6J	± kb
	transcript	NR_029468	RefSeq \| MGI Sequence Detail	606	C57BL/6

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All nucleic 3

cDNA 3

Microarray probesets 1

Summaries

All 28

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:389857 Liao J, et al., LncRNA Snhg12/IGFBP3 axis is involved in liver fibrosis by promoting the proliferation and activation of mouse hepatic stellate cells. J Cell Commun Signal. 2024 Jun;18(2):e12033

TSS for Snhg12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39367	Chr4:132035979-132035999 (+)	0 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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