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Ing2 Gene Detail
Summary
  • Symbol
    Ing2
  • Name
    inhibitor of growth family, member 2
  • Synonyms
    2810011M06Rik, Ing1l, ING2, P33ING2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916510
    NCBI Gene: 69260
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:48120213-48128591 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 26.87 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    205 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916510
 protein coding gene Chr8:48120213-48128627 (-)
129S1/SvImJ ENSMUSG00200005645
 protein coding gene Chr8:43206158-43249490 (-)
A/J ENSMUSG00195003976
 protein coding gene Chr8:43735257-43747099 (-)
AKR/J ENSMUSG00220004425
 protein coding gene Chr8:43536748-43548590 (-)
BALB/cJ ENSMUSG00180002642
 protein coding gene Chr8:43276242-43288084 (-)
C3H/HeJ ENSMUSG00175005159
 protein coding gene Chr8:43397829-43409673 (-)
C57BL/6NJ ENSMUSG00215009723
 protein coding gene Chr8:43207342-43219184 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031042
 protein coding gene Chr8:41247245-41255621 (-)
CAST/EiJ ENSTCUG00005018721
 protein coding gene Chr8:43222358-43233384 (-)
CBA/J ENSMUSG00210018637
 protein coding gene Chr8:43274846-43286689 (-)
DBA/2J ENSMUSG00185005907
 protein coding gene Chr8:49161814-49173658 (-)
FVB/NJ ENSMUSG00205002739
 protein coding gene Chr8:42404527-42416369 (-)
JF1/MsJ ENSUMUG00000004716
 protein coding gene Chr8:50766446-50778275 (-)
LP/J ENSMUSG00230014130
 protein coding gene Chr8:52813611-52825452 (-)
NOD/ShiLtJ ENSMUSG00190005952
 protein coding gene Chr8:43313414-43325256 (-)
NZO/HlLtJ ENSMUSG00225011821
 protein coding gene Chr8:56402257-56414098 (-)
PWK/PhJ ENSLUMG00010009054
 protein coding gene Chr8:43041547-43053335 (-)
SPRET/EiJ ENSMSPG00010005584
 protein coding gene Chr8:43930365-43942203 (-)
WSB/EiJ ENSIUOG00005002514
 protein coding gene Chr8:44136186-44148028 (-)



Homology
more
  • Human Ortholog
    ING2, inhibitor of growth family member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ING2, inhibitor of growth family member 2
  • Synonyms
    ING1L, ING1Lp, p33ING2
  • Links
    NCBI Gene ID: 3622
    UniProt: Q9H160

  • Chr Location
    4q35.1; chr4:183505058-183512429 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    3 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes impaired spermatogenesis and male infertility associated with teratozoospermia, seminiferous tubule degeneration, germ cell depletion, arrest of male meiosis and enhanced testicular apoptosis, and leads to an increased incidence of soft tissue sarcomas.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    825
  • Tissues
    204
  • cDNA Data
    23
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063049 Ensembl Gene Model | MGI Sequence Detail 8379 C57BL/6J ±  kb
    transcript ENSMUST00000080353 Ensembl | MGI Sequence Detail 2812 Not Applicable  
    polypeptide ENSMUSP00000079226 Ensembl | MGI Sequence Detail 281 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 23
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 12
    • Earliest
      J:320044 Zhang Y, et al., SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol Cell. 1998 Jun;1(7):1021-31
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory