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Srrm4 Gene Detail
Summary
  • Symbol
    Srrm4
  • Name
    serine/arginine repetitive matrix 4
  • Synonyms
    1500001A10Rik, B230202K19Rik, bv, flopsy, fp, mKIAA1853, nSR100
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916205
    NCBI Gene: 68955
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:116577334-116729876 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 56.45 cM, cytoband F
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4547 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916205
 protein coding gene Chr5:116577331-116729882 (-)
129S1/SvImJ ENSMUSG00200022890
 protein coding gene Chr5:110318049-110470955 (-)
A/J ENSMUSG00195031392
 protein coding gene Chr5:109840442-109993361 (-)
AKR/J ENSMUSG00220051326
 protein coding gene Chr5:109347766-109500687 (-)
BALB/cJ ENSMUSG00180045259
 protein coding gene Chr5:109968811-110121736 (-)
C3H/HeJ ENSMUSG00175021691
 protein coding gene Chr5:111956548-112109527 (-)
C57BL/6NJ ENSMUSG00215015310
 protein coding gene Chr5:109979146-110132142 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027638
 protein coding gene Chr5:109400118-109557372 (-)
CAST/EiJ ENSTCUG00005031691
 protein coding gene Chr5:109163340-109315608 (-)
CBA/J ENSMUSG00210033817
 protein coding gene Chr5:110707555-110860535 (-)
DBA/2J ENSMUSG00185042221
 protein coding gene Chr5:113776137-113930134 (-)
FVB/NJ ENSMUSG00205023507
 protein coding gene Chr5:109614779-109768022 (-)
JF1/MsJ ENSUMUG00000052271
 protein coding gene Chr5:116591919-116745388 (-)
LP/J ENSMUSG00230042805
 protein coding gene Chr5:117856108-118008969 (-)
NOD/ShiLtJ ENSMUSG00190044269
 protein coding gene Chr5:109644924-109797922 (-)
NZO/HlLtJ ENSMUSG00225013394
 protein coding gene Chr5:125525455-125679429 (-)
PWK/PhJ ENSLUMG00010024891
 protein coding gene Chr5:108482449-108635493 (-)
SPRET/EiJ ENSMSPG00010028730
 protein coding gene Chr5:111783283-111945005 (-)
WSB/EiJ ENSIUOG00005041253
 protein coding gene Chr5:112348689-112502900 (-)



Homology
more
  • Human Ortholog
    SRRM4, serine/arginine repetitive matrix 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRRM4, serine/arginine repetitive matrix 4
  • Synonyms
    KIAA1853, MU-MB-2.76, nSR100
  • Links
    NCBI Gene ID: 84530
    UniProt: A7MD48

  • Chr Location
    12q24.23; chr12:118981541-119163051 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    44 phenotypes from 4 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    7 images
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most homozygous null mice die neonatally with respiratory defects while survivors show tremors, head tilt, circling, premature neurogenesis, altered neurite outgrowth, cortical layering and axon guidance. Homozygotes for a spontaneous deletion show inner ear hair cell, balance and hearing defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    646
  • Tissues
    25
  • cDNA Data
    6
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063919 Ensembl Gene Model | MGI Sequence Detail 152543 C57BL/6J ±  kb
    transcript ENSMUST00000076124 Ensembl | MGI Sequence Detail 7472 Not Applicable  
    polypeptide ENSMUSP00000075488 Ensembl | MGI Sequence Detail 608 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000030470 serine/arginine repetitive matrix protein 4
      (term hierarchy)
    • InterPro Domains
      IPR052109 Serine/arginine repetitive matrix protein
      IPR029360 Serine/arginine repetitive matrix protein, C-terminal
    • GlyGen
      Q8BKA3 1 site
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 9
      Primer pair 4
      Other 3
      Antibodies 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-1687, MGD-MRK-9868, MGI:1925852, MGI:88220
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 44
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory