About   Help   FAQ
Cd177 Gene Detail
Summary
  • Symbol
    Cd177
  • Name
    CD177 antigen
  • Synonyms
    1190003K14Rik, Pdp3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916141
    NCBI Gene: 68891
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24443408-24459736 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 12.58 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    566 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916141
 protein coding gene Chr7:24443408-24459759 (-)
129S1/SvImJ ENSMUSG00200039693
 protein coding gene Chr7:14446436-14462766 (-)
A/J ENSMUSG00195051555
 protein coding gene Chr7:16883220-16899549 (-)
AKR/J ENSMUSG00220047250
 protein coding gene Chr7:27491042-27507373 (+)
BALB/cJ ENSMUSG00180053693
 protein coding gene Chr7:14955195-14971525 (-)
C3H/HeJ ENSMUSG00175050649
 protein coding gene Chr7:15999393-16015724 (-)
C57BL/6NJ ENSMUSG00215054668
 protein coding gene Chr7:14359183-14375513 (-)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005047864
 protein coding gene Chr7:16060847-16076917 (-)
CBA/J ENSMUSG00210052077
 protein coding gene Chr7:15185108-15201441 (-)
DBA/2J ENSMUSG00185053014
 protein coding gene Chr7:18398874-18415203 (-)
FVB/NJ ENSMUSG00205047306
 protein coding gene Chr7:15195661-15211992 (-)
JF1/MsJ ENSUMUG00000053978
 protein coding gene Chr7:22695472-22711874 (-)
LP/J ENSMUSG00230053593
 protein coding gene Chr7:23672797-23689126 (-)
NOD/ShiLtJ ENSMUSG00190049108
 protein coding gene Chr7:14667267-14683652 (-)
NZO/HlLtJ ENSMUSG00225026513
 protein coding gene Chr7:22340677-22357006 (-)
PWK/PhJ ENSLUMG00010042528
 protein coding gene Chr7:14629821-14646218 (-)
SPRET/EiJ ENSMSPG00010050185
 protein coding gene Chr7:14297693-14314021 (-)
WSB/EiJ ENSIUOG00005052004
 protein coding gene Chr7:9147155-9163467 (-)



Homology
more
  • Human Ortholog
    CD177, CD177 molecule
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD177, CD177 molecule
  • Synonyms
    HNA-2, HNA-2a, HNA2A, NB1, NB1 GP, PRV-1, PRV1
  • Links
    NCBI Gene ID: 57126
    UniProt: Q8N6Q3

  • Chr Location
    19q13.31; chr19:43353686-43366081 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased circulating neutrophils, increased neutrophil cell death and decreased neutrophils and monocytes early after S. aureus infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    603
  • Tissues
    5
  • cDNA Data
    26
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052212 Ensembl Gene Model | MGI Sequence Detail 16329 C57BL/6J ±  kb
transcript ENSMUST00000063956 Ensembl | MGI Sequence Detail 2714 Not Applicable  
polypeptide ENSMUSP00000064934 Ensembl | MGI Sequence Detail 817 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 26

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:48250 Iwama A, et al., Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha. Nucleic Acids Res. 1998 Jun 15;26(12):3034-43
  • Latest
    J:367366 Liang Y, et al., Integrated single-cell and spatial transcriptomic profiling reveals that CD177(+) Tregs enhance immunosuppression through apoptosis and resistance to immunotherapy in hepatocellular carcinoma. Oncogene. 2025 Jun;44(21):1578-1591
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory