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Arv1 Gene Detail
Summary
  • Symbol
    Arv1
  • Name
    ARV1 homolog, fatty acid homeostasis modulator
  • Synonyms
    1110067L22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916115
    NCBI Gene: 68865
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:125448878-125460862 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    490 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916115
 protein coding gene Chr8:125448765-125469533 (+)
129S1/SvImJ ENSMUSG00200041238
 protein coding gene Chr8:119701310-119713330 (+)
A/J ENSMUSG00195024933
 protein coding gene Chr8:119982670-119994673 (+)
AKR/J ENSMUSG00220038682
 protein coding gene Chr8:120171475-120183472 (+)
BALB/cJ ENSMUSG00180021251
 protein coding gene Chr8:120027525-120039532 (+)
C3H/HeJ ENSMUSG00175029075
 protein coding gene Chr8:120090900-120102897 (+)
C57BL/6NJ ENSMUSG00215031187
 protein coding gene Chr8:119680751-119692735 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031710
 protein coding gene Chr8:115868550-115880027 (+)
CAST/EiJ ENSTCUG00005031297
 protein coding gene Chr8:119434788-119446337 (+)
CBA/J ENSMUSG00210031409
 protein coding gene Chr8:120006738-120018723 (+)
DBA/2J ENSMUSG00185036307
 protein coding gene Chr8:126325682-126337666 (+)
FVB/NJ ENSMUSG00205029062
 protein coding gene Chr8:118979463-118991473 (+)
JF1/MsJ ENSUMUG00000030180
 protein coding gene Chr8:128535062-128547082 (+)
LP/J ENSMUSG00230027690
 protein coding gene Chr8:129883936-129902361 (+)
NOD/ShiLtJ ENSMUSG00190019127
 protein coding gene Chr8:120125980-120137966 (+)
NZO/HlLtJ ENSMUSG00225018886
 protein coding gene Chr8:133243624-133255608 (+)
PWK/PhJ ENSLUMG00010036898
 protein coding gene Chr8:119823671-119835597 (+)
SPRET/EiJ ENSMSPG00010001747
 protein coding gene Chr8:122010440-122020223 (+)
WSB/EiJ ENSIUOG00005026960
 protein coding gene Chr8:120800246-120812053 (+)



Homology
more
  • Human Ortholog
    ARV1, ARV1 fatty acid homeostasis modulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARV1, ARV1 fatty acid homeostasis modulator
  • Synonyms
    DEE38, EIEE38
  • Links
    NCBI Gene ID: 64801
    UniProt: Q9H2C2

  • Chr Location
    1q42.2; chr1:230978981-231000733 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ARV1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    72 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show reduced survivor rate, seizures, increased food intake, hyperactivity and metabolic changes including lack of weight gain, improved glucose tolerance, elevated adiponectin secretion, increased energy expenditure, reduced white fat amount, and resistance to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031982 Ensembl Gene Model | MGI Sequence Detail 11985 C57BL/6J ±  kb
    transcript ENSMUST00000034463 Ensembl | MGI Sequence Detail 1165 Not Applicable  
    polypeptide ENSMUSP00000034463 Ensembl | MGI Sequence Detail 266 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 27

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142557, MGI:2142764
    References
    more
    • Summaries
      All 40
      Gene Ontology 10
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory