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Mtmr14 Gene Detail
Summary
  • Symbol
    Mtmr14
  • Name
    myotubularin related protein 14
  • Synonyms
    1110061O04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916075
    NCBI Gene: 97287
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:113214804-113258353 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 52.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    871 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916075
 protein coding gene Chr6:113214596-113258353 (+)
129S1/SvImJ ENSMUSG00200024807
 protein coding gene Chr6:110264540-110308091 (+)
A/J ENSMUSG00195014678
 protein coding gene Chr6:109936973-109980524 (+)
AKR/J ENSMUSG00220031941
 protein coding gene Chr6:108860312-108903865 (+)
BALB/cJ ENSMUSG00180002189
 protein coding gene Chr6:110301693-110345250 (+)
C3H/HeJ ENSMUSG00175027527
 protein coding gene Chr6:67063180-67106733 (-)
C57BL/6NJ ENSMUSG00215013397
 protein coding gene Chr6:110296166-110339717 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028717
 protein coding gene Chr6:108317000-108360346 (+)
CAST/EiJ ENSTCUG00005027780
 protein coding gene Chr6:110104008-110147881 (+)
CBA/J ENSMUSG00210019887
 protein coding gene Chr6:110120232-110163782 (+)
DBA/2J ENSMUSG00185017222
 protein coding gene Chr6:110494107-110537696 (+)
FVB/NJ ENSMUSG00205022887
 protein coding gene Chr6:109194079-109237665 (+)
JF1/MsJ ENSUMUG00000011007
 protein coding gene Chr6:109227549-109268627 (+)
LP/J ENSMUSG00230045052
 protein coding gene Chr6:111765867-111809417 (+)
NOD/ShiLtJ ENSMUSG00190016984
 protein coding gene Chr6:109692883-109736468 (+)
NZO/HlLtJ ENSMUSG00225044416
 protein coding gene Chr6:113708384-113751971 (+)
PWK/PhJ ENSLUMG00010024324
 protein coding gene Chr6:108721614-108762683 (+)
SPRET/EiJ ENSMSPG00010033075
 protein coding gene Chr6:111489651-111532236 (+)
WSB/EiJ ENSIUOG00005022295
 protein coding gene Chr6:110447164-110490759 (+)



Homology
more
  • Human Ortholog
    MTMR14, myotubularin related protein 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTMR14, myotubularin related protein 14
  • Synonyms
    C3orf29
  • Links
    NCBI Gene ID: 64419
    UniProt: Q8NCE2

  • Chr Location
    3p25.3; chr3:9649433-9702393 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MTMR14 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice develop a muscle disorder due to impaired Ca2+ homeostasis. Males are sub-fertile with defects in spermatogenesis, sperm structure and motility, impaired acrosome reaction, decreased muscle force of vas deferens, and intracellular Ca2+ imbalance in the testes and epididymis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    600
  • Tissues
    2
  • cDNA Data
    135
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030269 Ensembl Gene Model | MGI Sequence Detail 43550 C57BL/6J ±  kb
    transcript ENSMUST00000113146 Ensembl | MGI Sequence Detail 2676 Not Applicable  
    polypeptide ENSMUSP00000108771 Ensembl | MGI Sequence Detail 648 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 136
      cDNA 135
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141698, MGI:2141743
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 22
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory