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Rgmb Gene Detail
Summary
  • Symbol
    Rgmb
  • Name
    repulsive guidance molecule family member B
  • Synonyms
    1110059F19Rik, DRAGON, RGM domain family, member B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916049
    NCBI Gene: 68799
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:16024923-16051508 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 8.96 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    606 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916049
 protein coding gene Chr17:16023450-16051508 (-)
129S1/SvImJ ENSMUSG00200036346
 protein coding gene Chr17:11634548-11662427 (-)
A/J ENSMUSG00195033153
 protein coding gene Chr17:12392033-12419925 (-)
AKR/J ENSMUSG00220023035
 protein coding gene Chr17:12053229-12081122 (-)
BALB/cJ ENSMUSG00180016314
 protein coding gene Chr17:11632459-11660352 (-)
C3H/HeJ ENSMUSG00175040208
 protein coding gene Chr17:11529831-11557698 (-)
C57BL/6NJ ENSMUSG00215040401
 protein coding gene Chr17:11731815-11759669 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021100
 protein coding gene Chr17:11404890-11424965 (-)
CAST/EiJ ENSTCUG00005021032
 protein coding gene Chr17:12045020-12072793 (-)
CBA/J ENSMUSG00210029834
 protein coding gene Chr17:11373867-11401731 (-)
DBA/2J ENSMUSG00185038331
 protein coding gene Chr17:13360612-13388502 (-)
FVB/NJ ENSMUSG00205017921
 protein coding gene Chr17:12042797-12070649 (-)
JF1/MsJ ENSUMUG00000018370
 protein coding gene Chr17:12922971-12950743 (-)
LP/J ENSMUSG00230021043
 protein coding gene Chr17:14758864-14786742 (-)
NOD/ShiLtJ ENSMUSG00190027273
 protein coding gene Chr17:11792550-11820372 (-)
NZO/HlLtJ ENSMUSG00225047615
 protein coding gene Chr17:16712441-16740320 (-)
PWK/PhJ ENSLUMG00010019911
 protein coding gene Chr17:11630645-11658440 (-)
SPRET/EiJ ENSMSPG00010034080
 protein coding gene Chr17:12941508-12966563 (-)
WSB/EiJ ENSIUOG00005034910
 protein coding gene Chr17:12383397-12411228 (-)



Homology
more
  • Human Ortholog
    RGMB, repulsive guidance molecule BMP co-receptor b
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RGMB, repulsive guidance molecule BMP co-receptor b
  • Synonyms
    DRAGON
  • Links
    NCBI Gene ID: 285704
    UniProt: Q6NW40

  • Chr Location
    5q15; chr5:98768004-98798643 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality at 2 to 3 weeks after birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1123
  • Tissues
    237
  • cDNA Data
    17
  • Literature Summary
    19
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68799 NCBI Gene Model | MGI Sequence Detail 26586 C57BL/6J ±  kb
transcript NM_001372258 RefSeq | MGI Sequence Detail 4481 C57BL/6  
polypeptide Q7TQ33 UniProt | EBI | MGI Sequence Detail 436 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 19
    Primer pair 2
    Other 3
    Antibodies 2

    Microarray probesets 8
References
more
  • Summaries
    All 50
    Developmental Gene Expression 19
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:340034 Park JS, et al., Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. Nature. 2023 May;617(7960):377-385
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory