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Ndufaf4 Gene Detail
Summary
  • Symbol
    Ndufaf4
  • Name
    NADH:ubiquinone oxidoreductase complex assembly factor 4
  • Synonyms
    1110007M04Rik, 3000003G13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915743
    NCBI Gene: 68493
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:24898083-24905001 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 10.52 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    319 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915743
 protein coding gene Chr4:24898083-24905001 (+)
129S1/SvImJ ENSMUSG00200011879
 protein coding gene Chr4:21611286-21618191 (+)
A/J ENSMUSG00195000189
 protein coding gene Chr4:22085658-22092563 (+)
AKR/J ENSMUSG00220014477
 protein coding gene Chr4:21835539-21842445 (+)
BALB/cJ ENSMUSG00180000134
 protein coding gene Chr4:21557721-21564626 (+)
C3H/HeJ ENSMUSG00175002265
 protein coding gene Chr4:22065467-22072385 (+)
C57BL/6NJ ENSMUSG00215000757
 protein coding gene Chr4:21682829-21689747 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025854
 protein coding gene Chr4:19847993-19854906 (+)
CAST/EiJ ENSTCUG00005000229
 protein coding gene Chr4:21557338-21564324 (+)
CBA/J ENSMUSG00210004480
 protein coding gene Chr4:21789571-21796489 (+)
DBA/2J ENSMUSG00185000307
 protein coding gene Chr4:21881154-21888072 (+)
FVB/NJ ENSMUSG00205000404
 protein coding gene Chr4:21362748-21369653 (+)
JF1/MsJ ENSUMUG00000002120
 protein coding gene Chr4:21825668-21832577 (+)
LP/J ENSMUSG00230000336
 protein coding gene Chr4:25163149-25169890 (+)
NOD/ShiLtJ ENSMUSG00190000233
 protein coding gene Chr4:21781096-21787995 (+)
NZO/HlLtJ ENSMUSG00225001787
 protein coding gene Chr4:29086891-29093788 (+)
PWK/PhJ ENSLUMG00010007493
 protein coding gene Chr4:21272940-21279790 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005004976
 protein coding gene Chr4:21525779-21532699 (+)



Homology
more
  • Human Ortholog
    NDUFAF4, NADH:ubiquinone oxidoreductase complex assembly factor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDUFAF4, NADH:ubiquinone oxidoreductase complex assembly factor 4
  • Synonyms
    bA22L21.1, C6orf66, HRPAP20, HSPC125, MC1DN15, My013
  • Links
    NCBI Gene ID: 29078
    UniProt: Q9P032

  • Chr Location
    6q16.1; chr6:96889313-96897894 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NDUFAF4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    687
  • Tissues
    10
  • cDNA Data
    10
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68493 NCBI Gene Model | MGI Sequence Detail 6919 C57BL/6J ±  kb
transcript NM_026742 RefSeq | MGI Sequence Detail 3632 C57BL/6  
polypeptide Q9D1H6 UniProt | EBI | MGI Sequence Detail 173 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008754 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4
    (term hierarchy)
  • InterPro Domains
    IPR009622 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 6
Other
Accession IDs
less
MGI:1914882, MGI:2140562
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:201547 Schlehe JS, et al., The mitochondrial disease associated protein Ndufaf2 is dispensable for Complex-1 assembly but critical for the regulation of oxidative stress. Neurobiol Dis. 2013 Oct;58:57-67
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory