Card19 MGI Mouse Gene Detail - MGI:1915730 - caspase recruitment domain family, member 19

Symbol

Card19
Name

caspase recruitment domain family, member 19
Synonyms

1110007C09Rik

Feature Type

protein coding gene
IDs

MGI:1915730
NCBI Gene: 68480
Alliance

genome feature page
Transcription Start Sites

12 TSS

Sequence Map

Chr13:49356426-49369471 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 25.15 cM
Mapping Data

2 experiments

SNPs within 2kb

375 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915730	protein coding gene	Chr13:49356426-49369513 (-)
129S1/SvImJ	ENSMUSG00200035742	protein coding gene	Chr13:46635161-46648357 (-)
A/J	ENSMUSG00195028893	protein coding gene	Chr13:45684789-45697961 (-)
AKR/J	ENSMUSG00220009052	protein coding gene	Chr13:45500997-45514197 (-)
BALB/cJ	ENSMUSG00180008147	protein coding gene	Chr13:45987054-46000250 (-)
C3H/HeJ	ENSMUSG00175027138	protein coding gene	Chr13:45957514-45970708 (-)
C57BL/6NJ	ENSMUSG00215005630	protein coding gene	Chr13:46104081-46117277 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018499	protein coding gene	Chr13:44435274-44448242 (-)
CAST/EiJ	ENSTCUG00005029221	protein coding gene	Chr13:46016924-46030149 (-)
CBA/J	ENSMUSG00210026747	protein coding gene	Chr13:45962891-45976090 (-)
DBA/2J	ENSMUSG00185030396	protein coding gene	Chr13:46776900-46790090 (-)
FVB/NJ	ENSMUSG00205010732	protein coding gene	Chr13:45745492-45758716 (-)
JF1/MsJ	ENSUMUG00000008867	protein coding gene	Chr13:46304680-46317888 (-)
LP/J	ENSMUSG00230028053	protein coding gene	Chr13:56097723-56110917 (-)
NOD/ShiLtJ	ENSMUSG00190011035	protein coding gene	Chr13:46181778-46195014 (-)
NZO/HlLtJ	ENSMUSG00225035938	protein coding gene	Chr13:49848077-49861271 (-)
PWK/PhJ	ENSLUMG00010020400	protein coding gene	Chr13:45160879-45174077 (-)
SPRET/EiJ	ENSMSPG00010027694	protein coding gene	Chr13:45292900-45305843 (-)
WSB/EiJ	ENSIUOG00005027089	protein coding gene	Chr13:45321295-45334502 (-)

Human Ortholog

CARD19, caspase recruitment domain family member 19

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CARD19, caspase recruitment domain family member 19
Synonyms

BinCARD, C9orf89
Links

HGNC:28148

NCBI Gene ID: 84270

UniProt: Q96LW7
Chr Location

9q22.31; chr9:93096161-93113283 (+) GRCh38

MGI Vertebrate Homology

Card19 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CARD19
Gene Tree

Card19

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotypes from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

5
Genomic Mutations

1 involving Card19
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available

Mice homozygous for a null allele display enhanced B cell tolerance.

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All GO Annotations

9
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

28
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase card19

ZFIN card19

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All Sequences

46
RefSeq

7
UniProt

3
CCDS

CCDS49260.1

Ensembl

ENSMUSG00000037960 (Evidence)
NCBI Gene

68480

			Length	Strain/Species	Flank
genomic	68480	NCBI Gene Model \| MGI Sequence Detail	13046	C57BL/6J	± kb
transcript	NR_184779	RefSeq \| MGI Sequence Detail	809	C57BL/6
polypeptide	Q9D1I2	UniProt \| EBI \| MGI Sequence Detail	183	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000060019 caspase recruitment domain-containing protein 19

(term hierarchy)
InterPro Domains

IPR042146 BinCARD, CARD domain

IPR043574 Caspase recruitment domain-containing protein 19

IPR011029 Death-like domain superfamily

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All nucleic 28

cDNA 28

Microarray probesets 3

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MGI:2145305

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 9
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:365237 Aoto M, et al., The splicing factor Acin1 is essential for embryonic development but has limited effects on muscle structure and homeostasis. Sci Rep. 2025;15(1):14017

TSS for Card19:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122468	Chr13:49369454-49369528 (-)	-20 bp
Tssr4065	Chr13:49369410-49369452 (-)	40 bp
Tssr122467	Chr13:49369334-49369379 (-)	114 bp
Tssr4064	Chr13:49369312-49369323 (-)	153 bp
Tssr122466	Chr13:49365837-49365849 (-)	3,628 bp
Tssr122465	Chr13:49363761-49363786 (-)	5,697 bp
Tssr122464	Chr13:49361531-49361545 (-)	7,933 bp
Tssr122463	Chr13:49361515-49361529 (-)	7,949 bp
Tssr122462	Chr13:49358983-49358995 (-)	10,482 bp
Tssr122461	Chr13:49358933-49358959 (-)	10,525 bp
Tssr122460	Chr13:49358904-49358918 (-)	10,560 bp
Tssr122459	Chr13:49357542-49357585 (-)	11,907 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29