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Tmem126b Gene Detail
Summary
  • Symbol
    Tmem126b
  • Name
    transmembrane protein 126B
  • Synonyms
    1110001A23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915722
    NCBI Gene: 68472
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:90118041-90125203 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 50.60 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    299 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915722
 protein coding gene Chr7:90116646-90125209 (-)
129S1/SvImJ ENSMUSG00200026804
 protein coding gene Chr7:76886134-76894693 (-)
A/J ENSMUSG00195038476
 protein coding gene Chr7:81410624-81419190 (-)
AKR/J ENSMUSG00220041907
 protein coding gene Chr7:74881682-74890253 (-)
BALB/cJ ENSMUSG00180036601
 protein coding gene Chr7:78086905-78095472 (-)
C3H/HeJ ENSMUSG00175033060
 protein coding gene Chr7:78777253-78785829 (-)
C57BL/6NJ ENSMUSG00215020234
 protein coding gene Chr7:77952802-77961368 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029987
 protein coding gene Chr7:93534032-93542024 (-)
CAST/EiJ ENSTCUG00005028941
 protein coding gene Chr7:81378274-81386953 (-)
CBA/J ENSMUSG00210037837
 protein coding gene Chr7:78619141-78627718 (-)
DBA/2J ENSMUSG00185030891
 protein coding gene Chr7:82948796-82957371 (-)
FVB/NJ ENSMUSG00205029074
 protein coding gene Chr7:78565062-78573637 (-)
JF1/MsJ ENSUMUG00000011796
 protein coding gene Chr7:87888386-87897009 (-)
LP/J ENSMUSG00230016370
 protein coding gene Chr7:89038071-89046646 (-)
NOD/ShiLtJ ENSMUSG00190025227
 protein coding gene Chr7:78831263-78839826 (-)
NZO/HlLtJ ENSMUSG00225010925
 protein coding gene Chr7:87312994-87321569 (-)
PWK/PhJ ENSLUMG00010035666
 protein coding gene Chr7:77086097-77094738 (-)
SPRET/EiJ ENSMSPG00010011454
 protein coding gene Chr7:78125065-78132792 (-)
WSB/EiJ ENSIUOG00005029821
 protein coding gene Chr7:79223476-79232062 (-)



Homology
more
  • Human Ortholog
    TMEM126B, transmembrane protein 126B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM126B, transmembrane protein 126B
  • Synonyms
    HT007, MC1DN29
  • Links
    NCBI Gene ID: 55863
    UniProt: Q8IUX1

  • Chr Location
    11q14.1; chr11:85628573-85636540 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TMEM126B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    4
  • Gene trapped
    3
  • Radiation induced
    3
  • Targeted
    2
  • Genomic Mutations
    4 involving Tmem126b
  • Find Mice (IMSR)
    19 strains or lines available
Homozygous knockout reduces high-fat diet-induced phenotypes such as obesity and kidney damage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    37
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68472 NCBI Gene Model | MGI Sequence Detail 7163 C57BL/6J ±  kb
transcript NM_026734 RefSeq | MGI Sequence Detail 858 C57BL/6  
polypeptide Q9D1R1 UniProt | EBI | MGI Sequence Detail 230 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 37

    Microarray probesets 3
References
more
  • Summaries
    All 60
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 33
  • Earliest
    J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
  • Latest
    J:291866 Weihong C, et al., Transmembrane protein 126B protects against high fat diet (HFD)-induced renal injury by suppressing dyslipidemia via inhibition of ROS. Biochem Biophys Res Commun. 2019 Jan 29;509(1):40-47
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory