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Gpt2 Gene Detail
Summary
  • Symbol
    Gpt2
  • Name
    glutamic pyruvate transaminase (alanine aminotransferase) 2
  • Synonyms
    4631422C05Rik, ALT2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915391
    NCBI Gene: 108682
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:86219205-86254189 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.61 cM, cytoband C2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1046 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915391
 protein coding gene Chr8:86219090-86255531 (+)
129S1/SvImJ ENSMUSG00200017087
 protein coding gene Chr8:80565334-80600334 (+)
A/J ENSMUSG00195025236
 protein coding gene Chr8:80933655-80968441 (+)
AKR/J ENSMUSG00220033247
 protein coding gene Chr8:80964339-80999340 (+)
BALB/cJ ENSMUSG00180018626
 protein coding gene Chr8:80768745-80803752 (+)
C3H/HeJ ENSMUSG00175025855
 protein coding gene Chr8:80869310-80904099 (+)
C57BL/6NJ ENSMUSG00215011071
 protein coding gene Chr8:80485905-80520891 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031339
 protein coding gene Chr8:76822890-76856793 (+)
CAST/EiJ ENSTCUG00005034583
 protein coding gene Chr8:80364371-80399183 (+)
CBA/J ENSMUSG00210032016
 protein coding gene Chr8:80856429-80891211 (+)
DBA/2J ENSMUSG00185035084
 protein coding gene Chr8:86965014-86999800 (+)
FVB/NJ ENSMUSG00205036775
 protein coding gene Chr8:79912268-79947048 (+)
JF1/MsJ ENSUMUG00000010964
 protein coding gene Chr8:89291365-89326349 (+)
LP/J ENSMUSG00230030647
 protein coding gene Chr8:90562276-90597272 (+)
NOD/ShiLtJ ENSMUSG00190014181
 protein coding gene Chr8:80940969-80975954 (+)
NZO/HlLtJ ENSMUSG00225039600
 protein coding gene Chr8:93976845-94011829 (+)
PWK/PhJ ENSLUMG00010025334
 protein coding gene Chr8:80618941-80653932 (+)
SPRET/EiJ ENSMSPG00010028924
 protein coding gene Chr8:82526711-82561039 (+)
WSB/EiJ ENSIUOG00005018506
 protein coding gene Chr8:81659063-81694047 (+)



Homology
more
  • Human Ortholog
    GPT2, glutamic--pyruvic transaminase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPT2, glutamic--pyruvic transaminase 2
  • Synonyms
    ALT2, GPT 2, MRT49, NEDSPM
  • Links
    NCBI Gene ID: 84706
    UniProt: Q8TD30

  • Chr Location
    16q11.2; chr16:46882857-46931298 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GPT2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    1 images
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hypoactivity, reduced postnatal brain growth, various metabolic defects in pathways involving amino acid metabolism, the TCA cycle and neuroprotective mechanisms, and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    106
  • cDNA Data
    118
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031700 Ensembl Gene Model | MGI Sequence Detail 34985 C57BL/6J ±  kb
    transcript ENSMUST00000034136 Ensembl | MGI Sequence Detail 3639 Not Applicable  
    polypeptide ENSMUSP00000034136 Ensembl | MGI Sequence Detail 522 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008209 alanine aminotransferase 2
      (term hierarchy)
    • EC
      2.6.1.2
    • InterPro Domains
      IPR045088 Aminotransferase ALAT1/2-like
      IPR004839 Aminotransferase, class I/classII, large domain
      IPR015424 Pyridoxal phosphate-dependent transferase
      IPR015421 Pyridoxal phosphate-dependent transferase, major domain
      IPR015422 Pyridoxal phosphate-dependent transferase, small domain
    • GlyGen
      Q8BGT5 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 120
      cDNA 118
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2138407, MGI:2142714, MGI:2142880
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 3
      Gene Ontology 12
      Phenotypes 48
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:382992 Montoya T, et al., Alanine catabolism as a targetable vulnerability for MYC-driven liver cancer. Cell Rep. 2026 Mar 17;45(4):117107
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory