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Kdelr1 Gene Detail
Summary
  • Symbol
    Kdelr1
  • Name
    KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
  • Synonyms
    8030486F04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915387
    NCBI Gene: 68137
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45522264-45533150 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.57 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    388 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915387
 protein coding gene Chr7:45522196-45533156 (+)
129S1/SvImJ ENSMUSG00200030390
 protein coding gene Chr7:33124854-33135791 (+)
A/J ENSMUSG00195043750
 protein coding gene Chr7:37152981-37163962 (+)
AKR/J ENSMUSG00220008698
 protein coding gene Chr7:31451402-31462365 (+)
BALB/cJ ENSMUSG00180032921
 protein coding gene Chr7:34028387-34039370 (+)
C3H/HeJ ENSMUSG00175027226
 protein coding gene Chr7:34560781-34571718 (+)
C57BL/6NJ ENSMUSG00215040908
 protein coding gene Chr7:33815083-33826044 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029749
 protein coding gene Chr7:47822625-47835712 (+)
CAST/EiJ ENSTCUG00005045559
 protein coding gene Chr7:37559483-37570431 (+)
CBA/J ENSMUSG00210038036
 protein coding gene Chr7:34926048-34937009 (+)
DBA/2J ENSMUSG00185037531
 protein coding gene Chr7:38807570-38818507 (+)
FVB/NJ ENSMUSG00205034560
 protein coding gene Chr7:34470615-34481576 (+)
JF1/MsJ ENSUMUG00000042836
 protein coding gene Chr7:43287327-43298264 (+)
LP/J ENSMUSG00230051233
 protein coding gene Chr7:44242354-44253318 (+)
NOD/ShiLtJ ENSMUSG00190048846
 protein coding gene Chr7:34798328-34809275 (+)
NZO/HlLtJ ENSMUSG00225013443
 protein coding gene Chr7:42441581-42452564 (+)
PWK/PhJ ENSLUMG00010046939
 protein coding gene Chr7:33760395-33771321 (+)
SPRET/EiJ ENSMSPG00010033416
 protein coding gene Chr7:33526754-33537924 (+)
WSB/EiJ ENSIUOG00005020421
 protein coding gene Chr7:35346206-35357177 (+)



Homology
more
  • Human Ortholog
    KDELR1, KDEL endoplasmic reticulum protein retention receptor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KDELR1, KDEL endoplasmic reticulum protein retention receptor 1
  • Synonyms
    ERD2, ERD2.1, HDEL, PM23
  • Links
    NCBI Gene ID: 10945
    UniProt: P24390

  • Chr Location
    19q13.33; chr19:48382575-48397412 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced single point mutation display thymus hypoplasia and a reduction in CD4+ as well as CD8+ T cell numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    626
  • Tissues
    20
  • cDNA Data
    160
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68137 NCBI Gene Model | MGI Sequence Detail 10887 C57BL/6J ±  kb
    transcript NM_133950 RefSeq | MGI Sequence Detail 1525 C57BL/6  
    polypeptide Q99JH8 UniProt | EBI | MGI Sequence Detail 212 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 161
      cDNA 161

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2142222
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 4
      Gene Ontology 12
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:380616 Lv X, et al., TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2. Acta Pharm Sin B. 2023 Apr;13(4):1631-1647
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory