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Rnls Pseudogene Detail
Summary
  • Symbol
    Rnls
  • Name
    renalase, FAD-dependent amine oxidase
  • Synonyms
    6530404N21Rik
Location &
Maps
more
  • Sequence Map
    Chr19:33115147-33369665 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 29.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    6473 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915045
 polymorphic pseudogene Chr19:33115140-33369695 (-)
129S1/SvImJ ENSMUSG00200020494
 protein coding gene Chr19:29836021-30090549 (-)
A/J ENSMUSG00195034404
 protein coding gene Chr19:30002211-30256754 (-)
AKR/J ENSMUSG00220018673
 protein coding gene Chr19:30061630-30321713 (-)
BALB/cJ ENSMUSG00180029087
 protein coding gene Chr19:30331125-30585647 (-)
C3H/HeJ ENSMUSG00175024858
 protein coding gene Chr19:29719962-29974496 (-)
C57BL/6NJ ENSMUSG00215017746
 protein coding gene Chr19:29754492-30009015 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022880
 protein coding gene Chr19:30137458-30384733 (-)
CAST/EiJ ENSTCUG00005018204
 protein coding gene Chr19:29570316-29822915 (-)
CBA/J ENSMUSG00210013912
 protein coding gene Chr19:29963338-30217877 (-)
DBA/2J ENSMUSG00185030778
 protein coding gene Chr19:30335409-30589940 (-)
FVB/NJ ENSMUSG00205010624
 protein coding gene Chr19:29730621-29989375 (-)
JF1/MsJ ENSUMUG00000030875
 protein coding gene Chr19:30586830-30852208 (-)
LP/J ENSMUSG00230033502
 protein coding gene Chr19:31122295-31376807 (-)
NOD/ShiLtJ ENSMUSG00190020883
 protein coding gene Chr19:29704558-29959071 (-)
NZO/HlLtJ ENSMUSG00225029207
 protein coding gene Chr19:34899090-35153993 (-)
PWK/PhJ ENSLUMG00010033717
 protein coding gene Chr19:29958416-30210595 (-)
SPRET/EiJ ENSMSPG00010031628
 protein coding gene Chr19:29931020-30213265 (-)
WSB/EiJ ENSIUOG00005027953
 protein coding gene Chr19:29415338-29670059 (-)



Homology
more
  • Human Ortholog
    RNLS, renalase, FAD dependent amine oxidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNLS, renalase, FAD dependent amine oxidase
  • Synonyms
    C10orf59, RENALASE
  • Links
    NCBI Gene ID: 55328
    UniProt: Q5VYX0

  • Chr Location
    10q23.31; chr10:88171523-88584530 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human RNLS associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit aggravated ischemic myocardial damage, increased heart rate, increased blood pressure and increased serum levels of dopamine, adrenaline and noradrenaline.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071573 Ensembl Gene Model | MGI Sequence Detail 254519 C57BL/6J ±  kb
    transcript ENSMUST00000096114 Ensembl | MGI Sequence Detail 1597 Not Applicable  
    polypeptide ENSMUSP00000093825 Ensembl | MGI Sequence Detail 342 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 2
    References
    more
    • Summaries
      All 45
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory