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Hemk2 Gene Detail
Summary
  • Symbol
    Hemk2
  • Name
    HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine
  • Synonyms
    5830445C04Rik, N6amt1, Pred28
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915018
    NCBI Gene: 67768
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:87151073-87165537 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 49.52 cM, cytoband C3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    702 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915018
 protein coding gene Chr16:87151073-87165630 (+)
129S1/SvImJ ENSMUSG00200037172
 protein coding gene Chr16:84015806-84030381 (+)
A/J ENSMUSG00195025644
 protein coding gene Chr16:83814794-83829339 (+)
AKR/J ENSMUSG00220015337
 protein coding gene Chr16:84017223-84031774 (+)
BALB/cJ ENSMUSG00180014904
 protein coding gene Chr16:83897894-83912447 (+)
C3H/HeJ ENSMUSG00175013133
 protein coding gene Chr16:84222460-84237007 (+)
C57BL/6NJ ENSMUSG00215015425
 protein coding gene Chr16:84030189-84044747 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020896
 protein coding gene Chr16:81864896-81877433 (+)
CAST/EiJ ENSTCUG00005018003
 protein coding gene Chr16:83595149-83609814 (+)
CBA/J ENSMUSG00210032342
 protein coding gene Chr16:84123744-84138300 (+)
DBA/2J ENSMUSG00185032061
 protein coding gene Chr16:84076775-84091330 (+)
FVB/NJ ENSMUSG00205016701
 protein coding gene Chr16:83863101-83877649 (+)
JF1/MsJ ENSUMUG00000017759
 protein coding gene Chr16:84149435-84163568 (+)
LP/J ENSMUSG00230030993
 protein coding gene Chr16:86576883-86591454 (+)
NOD/ShiLtJ ENSMUSG00190021866
 protein coding gene Chr16:84031633-84046178 (+)
NZO/HlLtJ ENSMUSG00225030804
 protein coding gene Chr16:89754265-89768821 (+)
PWK/PhJ ENSLUMG00010012237
 protein coding gene Chr16:83812893-83826833 (+)
SPRET/EiJ ENSMSPG00010028804
 protein coding gene Chr16:84947922-84962301 (+)
WSB/EiJ ENSIUOG00005018711
 protein coding gene Chr16:84022229-84036760 (+)



Homology
more
  • Human Ortholog
    HEMK2, HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HEMK2, HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine
  • Synonyms
    C21orf127, KMT9, m.HsaHemK2P, MTQ2, N6AMT, N6AMT1, PRED28, PrmC
  • Links
    NCBI Gene ID: 29104
    UniProt: Q9Y5N5

  • Chr Location
    21q21.3; chr21:28575598-28885373 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele fail to form a primitive streak and die between E7.5 and E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    663
  • Tissues
    65
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67768 NCBI Gene Model | MGI Sequence Detail 14465 C57BL/6J ±  kb
    transcript NM_026366 RefSeq | MGI Sequence Detail 1791 Not Specified  
    polypeptide Q6SKR2 UniProt | EBI | MGI Sequence Detail 214 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 15
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:8270358
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 2
      Gene Ontology 13
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:370117 Luo Y, et al., Loss of N-6 adenine-specific DNA methyltransferase 1 leads to meiotic prophase abnormalities and male sub-fertility in mice. Biol Reprod. 2025 Jun 15;112(6):1289-1303
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory