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Ppid Gene Detail
Summary
  • Symbol
    Ppid
  • Name
    peptidylprolyl isomerase D (cyclophilin D)
  • Synonyms
    4930564J03Rik, cyclophilin 40, CYP-40, cytoplasmic cyclophilin D, Ppidl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914988
    NCBI Gene: 67738
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:79498649-79510957 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 34.91 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    441 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914988
 protein coding gene Chr3:79498644-79511117 (+)
129S1/SvImJ ENSMUSG00200018847
 protein coding gene Chr3:76279514-76293064 (+)
A/J ENSMUSG00195011388
 protein coding gene Chr3:76342436-76355997 (+)
AKR/J ENSMUSG00220001449
 protein coding gene Chr3:76355588-76369153 (+)
BALB/cJ ENSMUSG00180001819
 protein coding gene Chr3:76434352-76447917 (+)
C3H/HeJ ENSMUSG00175007269
 protein coding gene Chr3:76280601-76294160 (+)
C57BL/6NJ ENSMUSG00215001990
 protein coding gene Chr3:76731262-76744831 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025085
 protein coding gene Chr3:72346055-72358631 (+)
CAST/EiJ ENSTCUG00005001678
 protein coding gene Chr3:75842147-75855852 (+)
CBA/J ENSMUSG00210025519
 protein coding gene Chr3:76363009-76376570 (+)
DBA/2J ENSMUSG00185012492
 protein coding gene Chr3:76519089-76532655 (+)
FVB/NJ ENSMUSG00205006313
 protein coding gene Chr3:75375755-75389321 (+)
JF1/MsJ ENSUMUG00000000844
 protein coding gene Chr3:76106044-76119335 (+)
LP/J ENSMUSG00230008883
 protein coding gene Chr3:78534168-78547716 (+)
NOD/ShiLtJ ENSMUSG00190002563
 protein coding gene Chr3:76853573-76867355 (+)
NZO/HlLtJ ENSMUSG00225005993
 protein coding gene Chr3:81249411-81262972 (+)
PWK/PhJ ENSLUMG00010006275
 protein coding gene Chr3:76175377-76188279 (+)
SPRET/EiJ ENSMSPG00010016676
 protein coding gene Chr3:76907044-76920321 (+)
WSB/EiJ ENSIUOG00005002808
 protein coding gene Chr3:76764570-76778129 (+)



Homology
more
  • Human Ortholog
    PPID, peptidylprolyl isomerase D
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPID, peptidylprolyl isomerase D
  • Synonyms
    CYP-40, CYPD
  • Links
    NCBI Gene ID: 5481
    UniProt: Q08752

  • Chr Location
    4q32.1; chr4:158709127-158723406 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    598
  • Tissues
    1
  • cDNA Data
    13
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027804 Ensembl Gene Model | MGI Sequence Detail 12309 C57BL/6J ±  kb
transcript ENSMUST00000029382 Ensembl | MGI Sequence Detail 1752 Not Applicable  
polypeptide ENSMUSP00000029382 Ensembl | MGI Sequence Detail 370 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013078 eukaryotic-type peptidyl-prolyl cis-trans isomerase D
    (term hierarchy)
  • EC
    5.2.1.8
  • InterPro Domains
    IPR029000 Cyclophilin-like domain superfamily
    IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
    IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
    IPR050754 Peptidyl-prolyl cis-trans isomerase FKBP4/5/8-like
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR019734 Tetratricopeptide repeat
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35888, MGI:107419
References
more
  • Summaries
    All 54
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 10
    Phenotypes 15
  • Earliest
    J:34612 Yokoi H, et al., The structure and complete nucleotide sequence of the human cyclophilin 40 (PPID) gene. Genomics. 1996 Aug 1;35(3):448-55
  • Latest
    J:373627 Latorre-Muro P, et al., Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity. Nat Cell Biol. 2025 Jan;27(1):130-140
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory