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Alkbh8 Gene Detail
Summary
  • Symbol
    Alkbh8
  • Name
    alkB homolog 8, tRNA methyltransferase
  • Synonyms
    4930562C03Rik, 8030431D03Rik, 9430088N01Rik, Abh8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914917
    NCBI Gene: 67667
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:3335151-3391154 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 2.02 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1026 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914917
 protein coding gene Chr9:3335140-3391154 (+)
129S1/SvImJ ENSMUSG00200022762
 protein coding gene Chr9:171927-227891 (+)
A/J ENSMUSG00195017898
 protein coding gene Chr9:93794-149782 (+)
AKR/J ENSMUSG00220018431
 protein coding gene Chr9:209173-264460 (+)
BALB/cJ ENSMUSG00180011348
 protein coding gene Chr9:234433-290422 (+)
C3H/HeJ ENSMUSG00175023698
 protein coding gene Chr9:156520-212513 (+)
C57BL/6NJ ENSMUSG00215005361
 protein coding gene Chr9:170290-226275 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005007093
 protein coding gene Chr9:248322-306551 (+)
CBA/J ENSMUSG00210010790
 protein coding gene Chr9:123226-179219 (+)
DBA/2J ENSMUSG00185005001
 protein coding gene Chr9:302460-358442 (+)
FVB/NJ ENSMUSG00205006699
 protein coding gene Chr9:283602-339583 (+)
JF1/MsJ ENSUMUG00000006607
 protein coding gene Chr9:296980-353095 (+)
LP/J ENSMUSG00230004406
 protein coding gene Chr9:755891-811871 (+)
NOD/ShiLtJ ENSMUSG00190021875
 protein coding gene Chr9:200547-256543 (+)
NZO/HlLtJ ENSMUSG00225015889
 protein coding gene Chr9:634607-690589 (+)
PWK/PhJ ENSLUMG00010006352
 protein coding gene Chr9:275338-331333 (+)
SPRET/EiJ ENSMSPG00010005309
 protein coding gene Chr9:209005-266721 (+)
WSB/EiJ ENSIUOG00005007256
 protein coding gene Chr9:91985-147976 (+)



Homology
more
  • Human Ortholog
    ALKBH8, alkB homolog 8, tRNA methyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALKBH8, alkB homolog 8, tRNA methyltransferase
  • Synonyms
    ABH8, MRT71, TRM9, TRMT9, TRMT9A
  • Links
    NCBI Gene ID: 91801
    UniProt: Q96BT7

  • Chr Location
    11q22.3; chr11:107502727-107565742 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ALKBH8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants show no obvious phenotype at 20 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    684
  • Tissues
    41
  • cDNA Data
    21
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67667 NCBI Gene Model | MGI Sequence Detail 56004 C57BL/6J ±  kb
    transcript NM_001405036 RefSeq | MGI Sequence Detail 2694 C57BL/6  
    polypeptide Q80Y20 UniProt | EBI | MGI Sequence Detail 664 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000003955 tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8
      (term hierarchy)
    • EC
      2.1.1.229
    • InterPro Domains
      IPR051422 AlkB Family tRNA Methyltransferase/Dioxygenase
      IPR034256 ALKBH8, RNA recognition motif
      IPR015095 Alkylated DNA repair protein AlkB, homologue 8, N-terminal
      IPR032857 Alpha-ketoglutarate-dependent dioxygenase alkB homologue 4
      IPR027450 Alpha-ketoglutarate-dependent dioxygenase AlkB-like
      IPR037151 Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily
      IPR013216 Methyltransferase type 11
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR005123 Oxoglutarate/iron-dependent dioxygenase domain
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    • GlyGen
      Q80Y20 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 21
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1924422, MGI:2442181
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:373436 Qian Y, et al., ALKBH8-mediated codon-specific translation promotes colorectal tumorigenesis. Nat Commun. 2025 Oct 13;16(1):9075
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory