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Uchl5 Gene Detail
Summary
  • Symbol
    Uchl5
  • Name
    ubiquitin carboxyl-terminal esterase L5
  • Synonyms
    5830413B11Rik, Uch37
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914848
    NCBI Gene: 56207
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:143653010-143683204 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 62.54 cM, cytoband F
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    842 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914848
 protein coding gene Chr1:143652993-143683204 (+)
129S1/SvImJ ENSMUSG00200007670
 protein coding gene Chr1:141130215-141160443 (+)
A/J ENSMUSG00195016348
 protein coding gene Chr1:140441998-140472650 (+)
AKR/J ENSMUSG00220002764
 protein coding gene Chr1:140215472-140245696 (+)
BALB/cJ ENSMUSG00180011237
 protein coding gene Chr1:140657337-140687533 (+)
C3H/HeJ ENSMUSG00175006610
 protein coding gene Chr1:140641339-140671993 (+)
C57BL/6NJ ENSMUSG00215013231
 protein coding gene Chr1:140586710-140616908 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014677
 protein coding gene Chr1:135038278-135069029 (+)
CAST/EiJ ENSTCUG00005013214
 protein coding gene Chr1:139424119-139454093 (+)
CBA/J ENSMUSG00210013848
 protein coding gene Chr1:140603355-140633998 (+)
DBA/2J ENSMUSG00185006879
 protein coding gene Chr1:144905964-144936154 (+)
FVB/NJ ENSMUSG00205002244
 protein coding gene Chr1:139818173-139848810 (+)
JF1/MsJ ENSUMUG00000011493
 protein coding gene Chr1:144222262-144254231 (+)
LP/J ENSMUSG00230000368
 protein coding gene Chr1:144419424-144449618 (+)
NOD/ShiLtJ ENSMUSG00190002800
 protein coding gene Chr1:140418002-140448208 (+)
NZO/HlLtJ ENSMUSG00225000079
 protein coding gene Chr1:148188888-148219118 (+)
PWK/PhJ ENSLUMG00010001917
 protein coding gene Chr1:139540950-139572921 (+)
SPRET/EiJ ENSMSPG00010012085
 protein coding gene Chr1:142429558-142460526 (+)
WSB/EiJ ENSIUOG00005028576
 protein coding gene Chr1:139952698-139982892 (+)



Homology
more
  • Human Ortholog
    UCHL5, ubiquitin C-terminal hydrolase L5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UCHL5, ubiquitin C-terminal hydrolase L5
  • Synonyms
    CGI-70, INO80R, UCH37, UCH-L5
  • Links
    NCBI Gene ID: 51377
    UniProt: Q9Y5K5

  • Chr Location
    1q31.2; chr1:193012246-193060080 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit embryonic lethality associated with abnormal brain development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    775
  • Tissues
    27
  • cDNA Data
    64
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018189 Ensembl Gene Model | MGI Sequence Detail 30195 C57BL/6J ±  kb
    transcript ENSMUST00000189936 Ensembl | MGI Sequence Detail 1696 Not Applicable  
    polypeptide ENSMUSP00000140106 Ensembl | MGI Sequence Detail 329 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 64
      Antibodies 1

      Microarray probesets 7
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:367356 Yue WY, et al., Non-Redundant Essential Roles of Proteasomal Ubiquitin Receptors Rpn10 and Rpn13 in Germ Cell Formation and Fertility. Cells. 2025 May 12;14(10)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory