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Bag4 Gene Detail
Summary
  • Symbol
    Bag4
  • Name
    BCL2-associated athanogene 4
  • Synonyms
    2410112I15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914634
    NCBI Gene: 67384
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:26254566-26275237 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 14.17 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    464 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914634
 protein coding gene Chr8:26254566-26275315 (-)
129S1/SvImJ ENSMUSG00200021121
 protein coding gene Chr8:21295577-21316336 (-)
A/J ENSMUSG00195004965
 protein coding gene Chr8:21837451-21858214 (-)
AKR/J ENSMUSG00220024450
 protein coding gene Chr8:21461027-21481788 (-)
BALB/cJ ENSMUSG00180005313
 protein coding gene Chr8:21362019-21382780 (-)
C3H/HeJ ENSMUSG00175006523
 protein coding gene Chr8:21424767-21445529 (-)
C57BL/6NJ ENSMUSG00215008471
 protein coding gene Chr8:21339697-21360444 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030929
 protein coding gene Chr8:20234026-20254940 (-)
CAST/EiJ ENSTCUG00005020372
 protein coding gene Chr8:21641754-21662549 (-)
CBA/J ENSMUSG00210013682
 protein coding gene Chr8:21361301-21382061 (-)
DBA/2J ENSMUSG00185037567
 protein coding gene Chr8:27161999-27182759 (-)
FVB/NJ ENSMUSG00205003214
 protein coding gene Chr8:20860169-20880931 (-)
JF1/MsJ ENSUMUG00000017444
 protein coding gene Chr8:29035716-29056122 (-)
LP/J ENSMUSG00230011383
 protein coding gene Chr8:30921500-30942258 (-)
NOD/ShiLtJ ENSMUSG00190004053
 protein coding gene Chr8:21394784-21415544 (-)
NZO/HlLtJ ENSMUSG00225019129
 protein coding gene Chr8:34542849-34563605 (-)
PWK/PhJ ENSLUMG00010025017
 protein coding gene Chr8:21410250-21430586 (-)
SPRET/EiJ ENSMSPG00010015967
 protein coding gene Chr8:21690061-21709055 (-)
WSB/EiJ ENSIUOG00005010427
 protein coding gene Chr8:22108074-22128817 (-)



Homology
more
  • Human Ortholog
    BAG4, BAG cochaperone 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BAG4, BAG cochaperone 4
  • Synonyms
    BAG-4, SODD
  • Links
    NCBI Gene ID: 9530
    UniProt: O95429

  • Chr Location
    8p11.23; chr8:38176533-38213301 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant animals may show enhanced cytokine response and increased IL-6 production following TNF challenge. Studies on two different alleles of this gene are not in agreement.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    604
  • Tissues
    7
  • cDNA Data
    15
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67384 NCBI Gene Model | MGI Sequence Detail 20672 C57BL/6J ±  kb
    transcript NM_026121 RefSeq | MGI Sequence Detail 4798 Not Specified  
    polypeptide Q8CI61 UniProt | EBI | MGI Sequence Detail 457 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 5
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory