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Acot13 Gene Detail
Summary
  • Symbol
    Acot13
  • Name
    acyl-CoA thioesterase 13
  • Synonyms
    0610006O17Rik, Them2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914084
    NCBI Gene: 66834
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:25001938-25015472 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 10.69 cM, cytoband A3.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    595 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914084
 protein coding gene Chr13:25001931-25015523 (-)
129S1/SvImJ ENSMUSG00200029139
 protein coding gene Chr13:22133275-22146845 (-)
A/J ENSMUSG00195037496
 protein coding gene Chr13:21282540-21296111 (-)
AKR/J ENSMUSG00220012259
 protein coding gene Chr13:21103679-21117248 (-)
BALB/cJ ENSMUSG00180021370
 protein coding gene Chr13:21601001-21614570 (-)
C3H/HeJ ENSMUSG00175029613
 protein coding gene Chr13:21607272-21620841 (-)
C57BL/6NJ ENSMUSG00215010695
 protein coding gene Chr13:21762816-21776385 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018353
 protein coding gene Chr13:20622495-20630852 (-)
CAST/EiJ ENSTCUG00005010003
 protein coding gene Chr13:21777717-21790795 (-)
CBA/J ENSMUSG00210026365
 protein coding gene Chr13:21562401-21575970 (-)
DBA/2J ENSMUSG00185020343
 protein coding gene Chr13:22384381-22397950 (-)
FVB/NJ ENSMUSG00205024131
 protein coding gene Chr13:21403071-21416641 (-)
JF1/MsJ ENSUMUG00000007787
 protein coding gene Chr13:22056082-22070016 (-)
LP/J ENSMUSG00230019138
 protein coding gene Chr13:31711399-31724968 (-)
NOD/ShiLtJ ENSMUSG00190026167
 protein coding gene Chr13:21383674-21397640 (-)
NZO/HlLtJ ENSMUSG00225045287
 protein coding gene Chr13:25496625-25510194 (-)
PWK/PhJ ENSLUMG00010029747
 protein coding gene Chr13:20919643-20933411 (-)
SPRET/EiJ ENSMSPG00010023949
 protein coding gene Chr13:20741802-20755128 (-)
WSB/EiJ ENSIUOG00005015688
 protein coding gene Chr13:20909441-20923262 (-)



Homology
more
  • Human Ortholog
    ACOT13, acyl-CoA thioesterase 13
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACOT13, acyl-CoA thioesterase 13
  • Synonyms
    HT012, PNAS-27, THEM2
  • Links
    NCBI Gene ID: 55856
    UniProt: Q9NPJ3

  • Chr Location
    6p22.3; chr6:24666921-24705065 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 1 allele in 2 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered adaptive thermorgenesis, decreased body weight, reduced white adipose tissue and abnormal hepatic lipid and glucose metabolism, especially in mice fed a high fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    619
  • Tissues
    3
  • cDNA Data
    77
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66834 NCBI Gene Model | MGI Sequence Detail 13535 C57BL/6J ±  kb
    transcript NM_025790 RefSeq | MGI Sequence Detail 686 C57BL/6  
    polypeptide Q9CQR4 UniProt | EBI | MGI Sequence Detail 140 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 78
      Genomic 1
      cDNA 77

      Microarray probesets 3
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 1
      Gene Ontology 15
      Phenotypes 25
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:373064 Imai N, et al., Up-regulation of thioesterase superfamily member 2 in skeletal muscle promotes hepatic steatosis and insulin resistance in mice. Hepatology. 2022 Jan;75(1):154-169
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory