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Iscu Gene Detail
Summary
  • Symbol
    Iscu
  • Name
    iron-sulfur cluster assembly enzyme
  • Synonyms
    2310020H20Rik, Nifun
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913633
    NCBI Gene: 66383
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:113910809-113916349 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 55.55 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    190 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913633
 protein coding gene Chr5:113910479-113916349 (+)
129S1/SvImJ ENSMUSG00200021723
 protein coding gene Chr5:107651486-107657026 (+)
A/J ENSMUSG00195032156
 protein coding gene Chr5:107161448-107166989 (+)
AKR/J ENSMUSG00220051171
 protein coding gene Chr5:106679803-106685343 (+)
BALB/cJ ENSMUSG00180045171
 protein coding gene Chr5:107301966-107307507 (+)
C3H/HeJ ENSMUSG00175046085
 protein coding gene Chr5:109281949-109287528 (+)
C57BL/6NJ ENSMUSG00215011438
 protein coding gene Chr5:107310820-107316360 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027581
 protein coding gene Chr5:106719265-106724474 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210042317
 protein coding gene Chr5:108034066-108039644 (+)
DBA/2J ENSMUSG00185043844
 protein coding gene Chr5:111086025-111091567 (+)
FVB/NJ ENSMUSG00205031603
 protein coding gene Chr5:106939666-106945207 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230043118
 protein coding gene Chr5:115189705-115195245 (+)
NOD/ShiLtJ ENSMUSG00190046675
 protein coding gene Chr5:106978906-106984445 (+)
NZO/HlLtJ ENSMUSG00225015320
 protein coding gene Chr5:122835846-122841385 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ISCU, iron-sulfur cluster assembly enzyme
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ISCU, iron-sulfur cluster assembly enzyme
  • Synonyms
    2310020H20Rik, HML, hnifU, ISU2, NIFU, NIFUN
  • Links
    NCBI Gene ID: 23479
    UniProt: Q9H1K1

  • Chr Location
    12q23.3; chr12:108561463-108569384 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Iscu
  • Find Mice (IMSR)
    7 strains or lines available
Homozygous null embryos die prior to implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    1
  • cDNA Data
    11
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025825 Ensembl Gene Model | MGI Sequence Detail 5541 C57BL/6J ±  kb
transcript ENSMUST00000112311 Ensembl | MGI Sequence Detail 1395 Not Applicable  
polypeptide ENSMUSP00000107930 Ensembl | MGI Sequence Detail 209 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000009113 iron-sulfur cluster assembly enzyme ISCU
    (term hierarchy)
  • PDB
    1WFZ
  • InterPro Domains
    IPR011339 Iron-sulfur cluster assembly scaffold protein IscU
    IPR002871 NIF system FeS cluster assembly, NifU, N-terminal
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11
    Antibodies 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147429
References
more
  • Summaries
    All 51
    Developmental Gene Expression 1
    Gene Ontology 14
    Phenotypes 10
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:264015 Roy AR, et al., The transcriptional regulator CCCTC-binding factor limits oxidative stress in endothelial cells. J Biol Chem. 2018 Jun 1;293(22):8449-8461
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory