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Pycr3 Gene Detail
Summary
  • Symbol
    Pycr3
  • Name
    pyrroline-5-carboxylate reductase 3
  • Synonyms
    1110058B13Rik, 2700073G24Rik, Pycrl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913444
    NCBI Gene: 66194
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:75788319-75793369 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 35.09 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    224 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913444
 protein coding gene Chr15:75788319-75793409 (-)
129S1/SvImJ ENSMUSG00200051681
 protein coding gene Chr15:72905828-72910906 (-)
A/J ENSMUSG00195048746
 protein coding gene Chr15:72880228-72885317 (-)
AKR/J ENSMUSG00220047290
 protein coding gene Chr15:72891296-72896375 (-)
BALB/cJ ENSMUSG00180051072
 protein coding gene Chr15:72706960-72712048 (-)
C3H/HeJ ENSMUSG00175049722
 protein coding gene Chr15:73068846-73073929 (-)
C57BL/6NJ ENSMUSG00215047594
 protein coding gene Chr15:72797382-72802471 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019903
 protein coding gene Chr15:69871370-69876464 (-)
CAST/EiJ ENSTCUG00005047239
 protein coding gene Chr15:72414853-72419916 (-)
CBA/J ENSMUSG00210039149
 protein coding gene Chr15:72844130-72849203 (-)
DBA/2J ENSMUSG00185050407
 protein coding gene Chr15:72822822-72827905 (-)
FVB/NJ ENSMUSG00205033422
 protein coding gene Chr15:72573531-72578604 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230051885
 protein coding gene Chr15:76186817-76191900 (-)
NOD/ShiLtJ ENSMUSG00190044324
 protein coding gene Chr15:72826485-72831556 (-)
NZO/HlLtJ ENSMUSG00225051183
 protein coding gene Chr15:76491323-76496406 (-)
PWK/PhJ ENSLUMG00010050239
 protein coding gene Chr15:72759133-72764213 (-)
SPRET/EiJ ENSMSPG00010044010
 protein coding gene Chr15:74383562-74388576 (-)
WSB/EiJ ENSIUOG00005036797
 protein coding gene Chr15:72883676-72888752 (-)



Homology
more
  • Human Ortholog
    PYCR3, pyrroline-5-carboxylate reductase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PYCR3, pyrroline-5-carboxylate reductase 3
  • Synonyms
    PYCRL
  • Links
    NCBI Gene ID: 65263
    UniProt: Q53H96

  • Chr Location
    8q24.3; chr8:143603210-143609773 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    83
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66194 NCBI Gene Model | MGI Sequence Detail 5051 C57BL/6J ±  kb
transcript NM_025412 RefSeq | MGI Sequence Detail 1302 C57BL/6  
polypeptide Q9DCC4 UniProt | EBI | MGI Sequence Detail 274 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013517 pyrroline-5-carboxylate reductase 3
    (term hierarchy)
  • EC
    1.5.1.2
  • InterPro Domains
    IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
    IPR036291 NAD(P)-binding domain superfamily
    IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal
    IPR029036 Pyrroline-5-carboxylate reductase, dimerisation domain
    IPR000304 Pyrroline-5-carboxylate reductase-like
Molecular
Reagents
less
  • All nucleic 83
    cDNA 83

    Microarray probesets 3
Other
Accession IDs
less
MGI:1914445, MGI:7482323
References
more
  • Summaries
    All 73
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 15
    Phenotypes 36
  • Earliest
    J:5163 DeLorenzo RJ, et al., Glutamate oxalate transaminase (GOT) genetics in Mus musculus: linkage, polymorphism, and phenotypes of the Got-2 and Got-1 loci. Biochem Genet. 1970 Apr;4(2):259-73
  • Latest
    J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory