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Kdg4 Gene Detail
Summary
  • Symbol
    Kdg4
  • Name
    alpha-ketoglutarate dehydrogenase subunit 4
  • Synonyms
    1110018B13Rik, Mrps36
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913378
    NCBI Gene: 66128
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:100872463-100881167 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 53.23 cM, cytoband D1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    321 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913378
 protein coding gene Chr13:100872448-100881167 (-)
129S1/SvImJ ENSMUSG00200008632
 protein coding gene Chr13:95363564-95372756 (-)
A/J ENSMUSG00195028515
 protein coding gene Chr13:95911418-95920647 (-)
AKR/J ENSMUSG00220025174
 protein coding gene Chr13:94332656-94341858 (-)
BALB/cJ ENSMUSG00180033114
 protein coding gene Chr13:96449808-96459008 (-)
C3H/HeJ ENSMUSG00175015859
 protein coding gene Chr13:96548274-96557474 (-)
C57BL/6NJ ENSMUSG00215023163
 protein coding gene Chr13:96524967-96534165 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018848
 protein coding gene Chr13:94508687-94509233 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210011728
 protein coding gene Chr13:95871917-95881111 (-)
DBA/2J ENSMUSG00185017080
 protein coding gene Chr13:99615927-99625124 (-)
FVB/NJ ENSMUSG00205019440
 protein coding gene Chr13:95243604-95252802 (-)
JF1/MsJ ENSUMUG00000020365
 protein coding gene Chr13:99241074-99250007 (-)
LP/J ENSMUSG00230033043
 protein coding gene Chr13:109776789-109785981 (-)
NOD/ShiLtJ ENSMUSG00190036252
 protein coding gene Chr13:96203606-96212800 (-)
NZO/HlLtJ ENSMUSG00225036672
 protein coding gene Chr13:102130483-102139680 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010008278
 protein coding gene Chr13:96627273-96635977 (-)
WSB/EiJ ENSIUOG00005033236
 protein coding gene Chr13:95286584-95295430 (-)



Homology
more
  • Human Ortholog
    KGD4, alpha-ketoglutarate dehydrogenase subunit 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KGD4, alpha-ketoglutarate dehydrogenase subunit 4
  • Synonyms
    DC47, MRP-S36, MRPS36
  • Links
    NCBI Gene ID: 92259
    UniProt: P82909

  • Chr Location
    5q13.2; chr5:69217712-69230158 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    611
  • Tissues
    13
  • cDNA Data
    10
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061474 Ensembl Gene Model | MGI Sequence Detail 8705 C57BL/6J ±  kb
transcript ENSMUST00000109333 Ensembl | MGI Sequence Detail 701 Not Applicable  
polypeptide ENSMUSP00000104957 Ensembl | MGI Sequence Detail 102 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010642 alpha-ketoglutarate dehydrogenase component 4
    (term hierarchy)
  • InterPro Domains
    IPR020373 Alpha-ketoglutarate dehydrogenase component 4/YMR-31
  • GlyGen
    Q9CQX8 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:8330112
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory