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Dynlt2b Gene Detail
Summary
  • Symbol
    Dynlt2b
  • Name
    dynein light chain Tctex-type 2B
  • Synonyms
    0610012D17Rik, 2410011K15Rik, Tctex1d2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913311
    NCBI Gene: 66061
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:32238520-32247917 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 22.69 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    295 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913311
 protein coding gene Chr16:32238520-32247917 (+)
129S1/SvImJ ENSMUSG00200035586
 protein coding gene Chr16:29258993-29268390 (+)
A/J ENSMUSG00195027634
 protein coding gene Chr16:28799730-28809104 (+)
AKR/J ENSMUSG00220030957
 protein coding gene Chr16:29092028-29101385 (+)
BALB/cJ ENSMUSG00180026254
 protein coding gene Chr16:29015593-29024964 (+)
C3H/HeJ ENSMUSG00175036326
 protein coding gene Chr16:29160303-29169672 (+)
C57BL/6NJ ENSMUSG00215015330
 protein coding gene Chr16:29043783-29053183 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020672
 protein coding gene Chr16:29429216-29438231 (+)
CAST/EiJ ENSTCUG00005034224
 protein coding gene Chr16:29431455-29440851 (+)
CBA/J ENSMUSG00210031174
 protein coding gene Chr16:29202302-29211669 (+)
DBA/2J ENSMUSG00185017607
 protein coding gene Chr16:29117780-29127147 (+)
FVB/NJ ENSMUSG00205018657
 protein coding gene Chr16:29131237-29140612 (+)
JF1/MsJ ENSUMUG00000020795
 protein coding gene Chr16:29297480-29307142 (+)
LP/J ENSMUSG00230028621
 protein coding gene Chr16:31686544-31695913 (+)
NOD/ShiLtJ ENSMUSG00190029090
 protein coding gene Chr16:29307181-29316546 (+)
NZO/HlLtJ ENSMUSG00225039329
 protein coding gene Chr16:34919595-34928960 (+)
PWK/PhJ ENSLUMG00010028771
 protein coding gene Chr16:29116121-29125779 (+)
SPRET/EiJ ENSMSPG00010018232
 protein coding gene Chr16:29106621-29115595 (+)
WSB/EiJ ENSIUOG00005032758
 protein coding gene Chr16:29285550-29294939 (+)



Homology
more
  • Human Ortholog
    DYNLT2B, dynein light chain Tctex-type 2B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DYNLT2B, dynein light chain Tctex-type 2B
  • Synonyms
    SRTD17, TCTEX1D2
  • Links
    NCBI Gene ID: 255758
    UniProt: Q8WW35

  • Chr Location
    3q29; chr3:196291219-196318310 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dynlt2b mouse models; 1 with human DYNLT2B associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 4 alleles in 4 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null allele display male infertility with oligoasthenozoospermia, defects in axoneme formation, reduced numbers of elongated spermatids, and defects in sperm flagellum morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    4
  • cDNA Data
    30
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66061 NCBI Gene Model | MGI Sequence Detail 9398 C57BL/6J ±  kb
    transcript NM_025329 RefSeq | MGI Sequence Detail 854 Not Specified  
    polypeptide Q9CQ66 UniProt | EBI | MGI Sequence Detail 144 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 30

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1913668, MGI:6458571
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:361529 Harima R, et al., TCTEX1D2 is essential for sperm flagellum formation in mice. Sci Rep. 2025 Jan 18;15(1):2413
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory