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Scel Gene Detail
Summary
  • Symbol
    Scel
  • Name
    sciellin
  • Synonyms
    9230114I02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891228
    NCBI Gene: 64929
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:103750778-103850233 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 52.51 cM, cytoband E
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3296 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891228
 protein coding gene Chr14:103750499-103850782 (+)
129S1/SvImJ ENSMUSG00200018034
 protein coding gene Chr14:92332018-92431471 (+)
A/J ENSMUSG00195018237
 protein coding gene Chr14:92435346-92534808 (+)
AKR/J ENSMUSG00220002146
 protein coding gene Chr14:91866623-91966089 (+)
BALB/cJ ENSMUSG00180004437
 protein coding gene Chr14:91918165-92017637 (+)
C3H/HeJ ENSMUSG00175013546
 protein coding gene Chr14:93809439-93908920 (+)
C57BL/6NJ ENSMUSG00215013627
 protein coding gene Chr14:92000505-92099970 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019575
 protein coding gene Chr14:93571297-93674829 (+)
CAST/EiJ ENSTCUG00005002778
 protein coding gene Chr14:93429224-93530844 (+)
CBA/J ENSMUSG00210007620
 protein coding gene Chr14:92497647-92597113 (+)
DBA/2J ENSMUSG00185010841
 protein coding gene Chr14:97671463-97770960 (+)
FVB/NJ ENSMUSG00205011969
 protein coding gene Chr14:91617074-91723491 (+)
JF1/MsJ ENSUMUG00000011220
 protein coding gene Chr14:108687848-108790584 (+)
LP/J ENSMUSG00230003678
 protein coding gene Chr14:109556790-109660167 (+)
NOD/ShiLtJ ENSMUSG00190009524
 protein coding gene Chr14:92277807-92377258 (+)
NZO/HlLtJ ENSMUSG00225025098
 protein coding gene Chr14:99936421-100035877 (+)
PWK/PhJ ENSLUMG00010004470
 protein coding gene Chr14:91542716-91649139 (+)
SPRET/EiJ ENSMSPG00010009360
 protein coding gene Chr14:95528396-95632419 (+)
WSB/EiJ ENSIUOG00005018087
 protein coding gene Chr14:91492414-91592371 (+)



Homology
more
  • Human Ortholog
    SCEL, sciellin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCEL, sciellin
  • Links
    NCBI Gene ID: 8796
    UniProt: O95171

  • Chr Location
    13q22.3; chr13:77535605-77646769 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile with normal hair morphology and development and normal skin morphology and barrier function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    639
  • Tissues
    34
  • cDNA Data
    23
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022123 Ensembl Gene Model | MGI Sequence Detail 99456 C57BL/6J ±  kb
    transcript ENSMUST00000095576 Ensembl | MGI Sequence Detail 2424 Not Applicable  
    polypeptide ENSMUSP00000093233 Ensembl | MGI Sequence Detail 652 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 23
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1925008
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:66221 Champliaud MF, et al., Gene characterization of sciellin (SCEL) and protein localization in vertebrate epithelia displaying barrier properties. Genomics. 2000 Dec 1;70(2):264-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory