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Supt16 Gene Detail
Summary
  • Symbol
    Supt16
  • Name
    SPT16, facilitates chromatin remodeling subunit
  • Synonyms
    Cdc68, Fact140, Spt16, Supt16h
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890948
    NCBI Gene: 114741
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:52397876-52434696 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    737 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890948
 protein coding gene Chr14:52397871-52434873 (-)
129S1/SvImJ ENSMUSG00200014642
 protein coding gene Chr14:41195324-41231619 (-)
A/J ENSMUSG00195021407
 protein coding gene Chr14:41424534-41460840 (-)
AKR/J ENSMUSG00220031390
 protein coding gene Chr14:40780430-40816735 (-)
BALB/cJ ENSMUSG00180039835
 protein coding gene Chr14:41053490-41089799 (-)
C3H/HeJ ENSMUSG00175039827
 protein coding gene Chr14:42707668-42743970 (-)
C57BL/6NJ ENSMUSG00215032710
 protein coding gene Chr14:41408506-41445510 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019236
 protein coding gene Chr14:44183737-44217801 (-)
CAST/EiJ ENSTCUG00005048354
 protein coding gene Chr14:43271342-43307701 (-)
CBA/J ENSMUSG00210032419
 protein coding gene Chr14:41407137-41443441 (-)
DBA/2J ENSMUSG00185053072
 protein coding gene Chr14:46324894-46361121 (-)
FVB/NJ ENSMUSG00205039824
 protein coding gene Chr14:40657733-40693953 (-)
JF1/MsJ ENSUMUG00000032628
 protein coding gene Chr14:58232760-58269246 (-)
LP/J ENSMUSG00230052356
 protein coding gene Chr14:58569931-58606230 (-)
NOD/ShiLtJ ENSMUSG00190022055
 protein coding gene Chr14:41092201-41128428 (-)
NZO/HlLtJ ENSMUSG00225049993
 protein coding gene Chr14:48868029-48904327 (-)
PWK/PhJ ENSLUMG00010029413
 protein coding gene Chr14:40620173-40656481 (-)
SPRET/EiJ ENSMSPG00010043442
 protein coding gene Chr14:44315750-44352739 (-)
WSB/EiJ ENSIUOG00005031786
 protein coding gene Chr14:40809940-40846367 (-)



Homology
more
  • Human Ortholog
    SUPT16H, SPT16 homolog, facilitates chromatin remodeling subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SUPT16H, SPT16 homolog, facilitates chromatin remodeling subunit
  • Synonyms
    CDC68, FACTP140, NEDDFAC, SPT16, SPT16/CDC68
  • Links
    NCBI Gene ID: 11198
    UniProt: Q9Y5B9

  • Chr Location
    14q11.2; chr14:21351472-21384042 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SUPT16H associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    54
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    7
  • Gene trapped
    46
  • Genomic Mutations
    1 involving Supt16
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    77 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    933
  • Tissues
    144
  • cDNA Data
    15
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 114741 NCBI Gene Model | MGI Sequence Detail 36821 C57BL/6J ±  kb
transcript NM_033618 RefSeq | MGI Sequence Detail 4491 ZRU/MplStud  
polypeptide Q920B9 UniProt | EBI | MGI Sequence Detail 1047 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015834 FACT complex subunit SPT16
    (term hierarchy)
  • InterPro Domains
    IPR036005 Creatinase/aminopeptidase-like
    IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal
    IPR040258 FACT complex subunit Spt16
    IPR048969 FACT complex subunit SPT16, C-terminal domain
    IPR013953 FACT complex subunit SPT16, middle domain
    IPR029148 FACT complex subunit SPT16, N-terminal lobe domain
    IPR033825 FACT complex subunit Spt16, peptidase M24-like domain
    IPR056595 FACT complex subunit SPT16, PH-like domain
    IPR013719 Histone chaperone RTT106/FACT complex subunit SPT16-like, middle domain
    IPR000994 Peptidase M24
    IPR011993 PH-like domain superfamily
  • GlyGen
    Q920B9 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 18
    cDNA 16
    Primer pair 2

    Microarray probesets 5
References
more
  • Summaries
    All 45
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:70807 McGuire MV, et al., The mouse Supt16h/Fact140 gene, encoding part of the FACT chromatin transcription complex, maps close to Tcra and is highly expressed in thymus. Mamm Genome. 2001 Aug;12(8):664-7
  • Latest
    J:344671 Wang J, et al., Supt16 haploinsufficiency causes neurodevelopment disorder by disrupting MAPK pathway in neural stem cells. Hum Mol Genet. 2023 Feb 19;32(5):860-872
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory