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Il19 Gene Detail
Summary
  • Symbol
    Il19
  • Name
    interleukin 19
Location &
Maps
more
  • Sequence Map
    Chr1:130860393-130867852 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 56.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    292 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890472
 protein coding gene Chr1:130860393-130873194 (-)
129S1/SvImJ ENSMUSG00200007983
 protein coding gene Chr1:128431377-128438829 (-)
A/J ENSMUSG00195044021
 protein coding gene Chr1:127522622-127530082 (-)
AKR/J ENSMUSG00220043850
 protein coding gene Chr1:127368364-127375814 (-)
BALB/cJ ENSMUSG00180037730
 protein coding gene Chr1:128085939-128093394 (-)
C3H/HeJ ENSMUSG00175036966
 protein coding gene Chr1:127767338-127774796 (-)
C57BL/6NJ ENSMUSG00215042663
 protein coding gene Chr1:127783019-127790485 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014564
 protein coding gene Chr1:122510338-122517662 (-)
CAST/EiJ ENSTCUG00005033385
 protein coding gene Chr1:126704920-126712390 (-)
CBA/J ENSMUSG00210026031
 protein coding gene Chr1:127685625-127693079 (-)
DBA/2J ENSMUSG00185029833
 protein coding gene Chr1:132030196-132037648 (-)
FVB/NJ ENSMUSG00205031290
 protein coding gene Chr1:126987975-126995427 (-)
JF1/MsJ ENSUMUG00000001170
 protein coding gene Chr1:131204383-131211878 (-)
LP/J ENSMUSG00230000958
 protein coding gene Chr1:131609547-131616998 (-)
NOD/ShiLtJ ENSMUSG00190041752
 protein coding gene Chr1:127677271-127684732 (-)
NZO/HlLtJ ENSMUSG00225019949
 protein coding gene Chr1:135346335-135353787 (-)
PWK/PhJ ENSLUMG00010026973
 protein coding gene Chr1:126810219-126817721 (-)
SPRET/EiJ ENSMSPG00010043393
 protein coding gene Chr1:129622956-129629975 (-)
WSB/EiJ ENSIUOG00005040630
 protein coding gene Chr1:127436120-127443923 (-)



Homology
more
  • Human Ortholog
    IL19, interleukin 19
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL19, interleukin 19
  • Synonyms
    IL-10C, MDA1, NG.1, ZMDA1
  • Links
    NCBI Gene ID: 29949
    UniProt: Q9UHD0

  • Chr Location
    1q32.1; chr1:206770764-206842981 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit interleukin-23 (IL-23)-dependent epidermal hyperplasia. Mice homozygous for a different knock-out allele exhibit increased susceptibility to induced colitis with reduced B cell infiltration in chronic colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    603
  • Tissues
    3
  • cDNA Data
    1
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016524 Ensembl Gene Model | MGI Sequence Detail 7460 C57BL/6J ±  kb
    transcript ENSMUST00000112465 Ensembl | MGI Sequence Detail 880 Not Applicable  
    polypeptide ENSMUSP00000108084 Ensembl | MGI Sequence Detail 176 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 2
      cDNA 1
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 24
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:379882 Peluzzo AM, et al., IL-19 Is a Novel Lymphangiocrine Factor Inducing Lymphangiogenesis and Lymphatic Junctional Regulation. Arterioscler Thromb Vasc Biol. 2025 Jul;45(7):1244-1265
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory