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Cks1b Gene Detail
Summary
  • Symbol
    Cks1b
  • Name
    CDC28 protein kinase 1b
  • Synonyms
    2410005G18Rik, 2610005D03Rik, Cks1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889208
    NCBI Gene: 54124
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:89322779-89325598 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.11 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889208
 protein coding gene Chr3:89322779-89325690 (-)
129S1/SvImJ ENSMUSG00200037727
 protein coding gene Chr3:86178026-86180937 (-)
A/J ENSMUSG00195050767
 protein coding gene Chr3:86193056-86195967 (-)
AKR/J ENSMUSG00220047580
 protein coding gene Chr3:86147612-86150523 (-)
BALB/cJ ENSMUSG00180046849
 protein coding gene Chr3:86275142-86278054 (-)
C3H/HeJ ENSMUSG00175043367
 protein coding gene Chr3:86125676-86128587 (-)
C57BL/6NJ ENSMUSG00215049258
 protein coding gene Chr3:86565789-86568700 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025209
 protein coding gene Chr3:82145898-82149171 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210039707
 protein coding gene Chr3:86263309-86266220 (-)
DBA/2J ENSMUSG00185047057
 protein coding gene Chr3:86363589-86366501 (-)
FVB/NJ ENSMUSG00205042513
 protein coding gene Chr3:85187281-85190192 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230032310
 protein coding gene Chr3:88399330-88402241 (-)
NOD/ShiLtJ ENSMUSG00190034364
 protein coding gene Chr3:86648485-86651398 (-)
NZO/HlLtJ ENSMUSG00225007149
 protein coding gene Chr3:91154617-91157528 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CKS1B, CDC28 protein kinase regulatory subunit 1B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CKS1B, CDC28 protein kinase regulatory subunit 1B
  • Synonyms
    CKS1, ckshs1, PNAS-16, PNAS-18
  • Links
    NCBI Gene ID: 1163
    UniProt: P61024

  • Chr Location
    1q21.3; chr1:154974641-154979251 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out allele exhibit a reduced body size that persists through adulthood while heterozygous mice are intermediate in size. Mutant mouse embryonic fibroblasts (MEFs) proliferate poorly and senesce earlier than wild-type MEFs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    615
  • Tissues
    13
  • cDNA Data
    123
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54124 NCBI Gene Model | MGI Sequence Detail 2820 C57BL/6J ±  kb
    transcript NM_016904 RefSeq | MGI Sequence Detail 757 Not Specified  
    polypeptide P61025 UniProt | EBI | MGI Sequence Detail 79 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000005518 cyclin-dependent kinases regulatory subunit 1
      (term hierarchy)
    • InterPro Domains
      IPR000789 Cyclin-dependent kinase, regulatory subunit
      IPR036858 Cyclin-dependent kinase, regulatory subunit superfamily
    Molecular
    Reagents
    less
    • All nucleic 125
      cDNA 124
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1913740, MGI:1914364, MGI:2139555
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 4
      Phenotypes 24
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:361918 Xue Y, et al., Distinct outcomes from targeted perturbations of the multi-subunit SCF(Skp2) E3 ubiquitin ligase in blocking Trp53/Rb1-null prostate tumorigenesis. Commun Biol. 2025 Feb 22;8(1):278
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory