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Prdx5 Gene Detail
Summary
  • Symbol
    Prdx5
  • Name
    peroxiredoxin 5
  • Synonyms
    AOEB166, AOPP, peroxiredoxin V, PMP20, Prdx6, PrxV, PrxV
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859821
    NCBI Gene: 54683
  • Alliance
    genome feature page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6884065-6887474 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.08 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    14
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859821
 protein coding gene Chr19:6884065-6887474 (-)
129S1/SvImJ ENSMUSG00200051716
 protein coding gene Chr19:3609569-3613294 (-)
A/J ENSMUSG00195049891
 protein coding gene Chr19:4011483-4015208 (-)
AKR/J ENSMUSG00220046204
 protein coding gene Chr19:3780920-3784645 (-)
BALB/cJ ENSMUSG00180045238
 protein coding gene Chr19:4375054-4378779 (-)
C3H/HeJ ENSMUSG00175011679
 protein coding gene Chr19:3631495-3635220 (-)
C57BL/6NJ ENSMUSG00215040927
 protein coding gene Chr19:3849986-3853712 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022614
 protein coding gene Chr19:3576894-3580384 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210049406
 protein coding gene Chr19:3634842-3638567 (-)
DBA/2J ENSMUSG00185047266
 protein coding gene Chr19:4011316-4015041 (-)
FVB/NJ ENSMUSG00205028731
 protein coding gene Chr19:4010210-4014393 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230053583
 protein coding gene Chr19:4936303-4940028 (-)
NOD/ShiLtJ ENSMUSG00190046471
 protein coding gene Chr19:3542769-3546417 (-)
NZO/HlLtJ ENSMUSG00225026587
 protein coding gene Chr19:8645121-8648846 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PRDX5, peroxiredoxin 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRDX5, peroxiredoxin 5
  • Synonyms
    ACR1, AOEB166, B166, HEL-S-55, PLP, PMP20, PRDX6, prx-V, PRXV, SBBI10
  • Links
    NCBI Gene ID: 25824
    UniProt: P30044

  • Chr Location
    11q13.1; chr11:64318041-64321822 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show increased susceptibility to high fat diet-induced obesity and hepatic steatosis. Mice homozygous for a different null allele show elevated nitric oxide production and oxidative stress in bone-marrow-derived dendritic cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    688
  • Tissues
    77
  • cDNA Data
    249
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54683 NCBI Gene Model | MGI Sequence Detail 3410 C57BL/6J ±  kb
    transcript NM_012021 RefSeq | MGI Sequence Detail 1271 ZRU/MplStud  
    polypeptide P99029 UniProt | EBI | MGI Sequence Detail 210 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 250
      cDNA 249
      Primer pair 1
      Antibodies 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1349456
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 9
      Gene Ontology 15
      Phenotypes 16
    • Earliest
      J:58008 Yamashita H, et al., Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro. J Biol Chem. 1999 Oct 15;274(42):29897-904
    • Latest
      J:379037 Kweon HY, et al., Extracellular peroxiredoxin 5 exacerbates atherosclerosis via the TLR4/MyD88 pathway. Atherosclerosis. 2025 Jan;400:119052
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory