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Ramp1 Gene Detail
Summary
  • Symbol
    Ramp1
  • Name
    receptor (calcitonin) activity modifying protein 1
  • Synonyms
    9130218E19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858418
    NCBI Gene: 51801
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:91107544-91152918 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 46.08 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1281 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858418
 protein coding gene Chr1:91107544-91152918 (+)
129S1/SvImJ ENSMUSG00200035840
 protein coding gene Chr1:88334154-88379540 (+)
A/J ENSMUSG00195027361
 protein coding gene Chr1:87885958-87931506 (+)
AKR/J ENSMUSG00220043699
 protein coding gene Chr1:88043504-88088900 (+)
BALB/cJ ENSMUSG00180016421
 protein coding gene Chr1:88200550-88245908 (+)
C3H/HeJ ENSMUSG00175001275
 protein coding gene Chr1:88071808-88117352 (+)
C57BL/6NJ ENSMUSG00215016670
 protein coding gene Chr1:88007963-88053345 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014416
 protein coding gene Chr1:83635206-83680566 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210011566
 protein coding gene Chr1:87917085-87962626 (+)
DBA/2J ENSMUSG00185013497
 protein coding gene Chr1:92386934-92432290 (+)
FVB/NJ ENSMUSG00205018972
 protein coding gene Chr1:87331546-87376944 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230018866
 protein coding gene Chr1:91670327-91715702 (+)
NOD/ShiLtJ ENSMUSG00190024228
 protein coding gene Chr1:87968164-88013528 (+)
NZO/HlLtJ ENSMUSG00225002397
 protein coding gene Chr1:95571728-95617105 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    RAMP1, receptor activity modifying protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAMP1, receptor activity modifying protein 1
  • Links
    NCBI Gene ID: 10267
    UniProt: O60894

  • Chr Location
    2q37.3; chr2:237858880-237912111 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit high systolic blood pressure due to a disruption in vasodilatory regulation as well as significantly increased serum levels of proinflammatory cytokines following LPS administration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    739
  • Tissues
    50
  • cDNA Data
    33
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 51801 NCBI Gene Model | MGI Sequence Detail 45375 C57BL/6J ±  kb
    transcript NM_016894 RefSeq | MGI Sequence Detail 2549 ZRU/MplStud  
    polypeptide Q9WTJ5 UniProt | EBI | MGI Sequence Detail 148 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 33

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1924927
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 63
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:378274 Zhang W, et al., Neuro-epithelial circuits promote sensory convergence and intestinal immunity. Nature. 2026 Jan 7;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory