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Nxf1 Gene Detail
Summary
  • Symbol
    Nxf1
  • Name
    nuclear RNA export factor 1
  • Synonyms
    Mex67, Mvb1, TAP, Tip associated protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858330
    NCBI Gene: 53319
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:8734467-8748274 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.50 cM, cytoband A
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    277 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858330
 protein coding gene Chr19:8734437-8748286 (+)
129S1/SvImJ ENSMUSG00200047893
 protein coding gene Chr19:5460248-5465937 (+)
129S1/SvImJ ENSMUSGG00200055018
 protein coding gene Chr19:5466634-5468392 (+)
A/J ENSMUSGG00195055557
 protein coding gene Chr19:5868139-5869897 (+)
A/J ENSMUSG00195047482
 protein coding gene Chr19:5861744-5867442 (+)
AKR/J ENSMUSGG00220054983
 protein coding gene Chr19:5641366-5643124 (+)
AKR/J ENSMUSG00220048551
 protein coding gene Chr19:5634986-5640669 (+)
BALB/cJ ENSMUSGG00180055642
 protein coding gene Chr19:6232118-6233876 (+)
BALB/cJ ENSMUSG00180038160
 protein coding gene Chr19:6225729-6231421 (+)
C3H/HeJ ENSMUSGG00175055199
 protein coding gene Chr19:5505878-5507636 (+)
C3H/HeJ ENSMUSG00175013042
 protein coding gene Chr19:5499483-5505181 (+)
C57BL/6NJ ENSMUSGG00215055868
 protein coding gene Chr19:5707081-5708839 (+)
C57BL/6NJ ENSMUSG00215046069
 protein coding gene Chr19:5700693-5706384 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022651
 protein coding gene Chr19:5952928-5969090 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210040086
 protein coding gene Chr19:5515207-5520893 (+)
CBA/J ENSMUSGG00210055100
 protein coding gene Chr19:5521591-5523348 (+)
DBA/2J ENSMUSGG00185058009
 protein coding gene Chr19:5876280-5878037 (+)
DBA/2J ENSMUSG00185051485
 protein coding gene Chr19:5869895-5875582 (+)
FVB/NJ ENSMUSG00205047217
 protein coding gene Chr19:5557693-5563373 (+)
FVB/NJ ENSMUSGG00205054717
 protein coding gene Chr19:5564071-5565829 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055927
 protein coding gene Chr19:6793292-6795050 (+)
LP/J ENSMUSG00230052259
 protein coding gene Chr19:6786906-6792595 (+)
NOD/ShiLtJ ENSMUSGG00190055164
 protein coding gene Chr19:5401685-5403443 (+)
NOD/ShiLtJ ENSMUSG00190044696
 protein coding gene Chr19:5395299-5400988 (+)
NZO/HlLtJ ENSMUSG00225044843
 protein coding gene Chr19:10495705-10501390 (+)
NZO/HlLtJ ENSMUSGG00225055575
 protein coding gene Chr19:10502087-10503845 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010042180
 protein coding gene Chr19:5448475-5463010 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    NXF1, nuclear RNA export factor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NXF1, nuclear RNA export factor 1
  • Synonyms
    MEX67, TAP
  • Links
    NCBI Gene ID: 10482
    UniProt: Q9UBU9

  • Chr Location
    11q12.3; chr11:62792123-62806302 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotypes from multigenic genotypes
    12 phenotype references
Mice homozygous for some alleles are able to suppress defects caused by retrovirus insertion mutations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    630
  • Tissues
    33
  • cDNA Data
    11
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 53319 NCBI Gene Model | MGI Sequence Detail 13808 C57BL/6J ±  kb
transcript NM_001276704 RefSeq | MGI Sequence Detail 4035 ZRU/MplStud  
polypeptide Q99JX7 UniProt | EBI | MGI Sequence Detail 618 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000011535 nuclear RNA export factor 1
    (term hierarchy)
  • InterPro Domains
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
    IPR032710 NTF2-like domain superfamily
    IPR030217 Nuclear RNA export factor
    IPR015245 Nuclear RNA export factor Tap, RNA-binding domain
    IPR002075 Nuclear transport factor 2 domain
    IPR018222 Nuclear transport factor 2, eukaryote
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR057125 NXF1/2/3/5-like, leucine-rich repeat domain
    IPR035979 RNA-binding domain superfamily
    IPR005637 TAP C-terminal (TAP-C) domain
    IPR009060 UBA-like superfamily
  • GlyGen
    Q99JX7 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 16
    cDNA 14
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1194888
References
more
  • Summaries
    All 55
    Developmental Gene Expression 3
    Gene Ontology 11
    Phenotypes 12
  • Earliest
    J:40754 Hamilton BA, et al., The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May;18(5):711-22
  • Latest
    J:380828 Al Adhami H, et al., Systematic identification of factors involved in the silencing of germline genes in mouse embryonic stem cells. Nucleic Acids Res. 2023 Apr 24;51(7):3130-3149
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory