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Tmod2 Gene Detail
Summary
  • Symbol
    Tmod2
  • Name
    tropomodulin 2
  • Synonyms
    neural tropomodulin, N-Tmod, NTMOD
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355335
    NCBI Gene: 50876
  • Alliance
    genome feature page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:75472903-75518607 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 42.31 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1394 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355335
 protein coding gene Chr9:75472903-75518620 (-)
129S1/SvImJ ENSMUSG00200018863
 protein coding gene Chr9:72577863-72623572 (-)
A/J ENSMUSG00195009426
 protein coding gene Chr9:72330167-72376266 (-)
AKR/J ENSMUSG00220014929
 protein coding gene Chr9:72456548-72502638 (-)
BALB/cJ ENSMUSG00180018032
 protein coding gene Chr9:72442754-72488849 (-)
C3H/HeJ ENSMUSG00175011339
 protein coding gene Chr9:72478682-72524769 (-)
C57BL/6NJ ENSMUSG00215009053
 protein coding gene Chr9:72427027-72472737 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032444
 protein coding gene Chr9:72591040-72637363 (-)
CAST/EiJ ENSTCUG00005009223
 protein coding gene Chr9:72197617-72243307 (-)
CBA/J ENSMUSG00210013058
 protein coding gene Chr9:72533182-72579288 (-)
DBA/2J ENSMUSG00185006778
 protein coding gene Chr9:72563634-72609727 (-)
FVB/NJ ENSMUSG00205016653
 protein coding gene Chr9:72850941-72897039 (-)
JF1/MsJ ENSUMUG00000029245
 protein coding gene Chr9:72579049-72624843 (-)
LP/J ENSMUSG00230023828
 protein coding gene Chr9:72754718-72800424 (-)
NOD/ShiLtJ ENSMUSG00190028224
 protein coding gene Chr9:72658337-72704429 (-)
NZO/HlLtJ ENSMUSG00225025217
 protein coding gene Chr9:72861119-72907217 (-)
PWK/PhJ ENSLUMG00010015579
 protein coding gene Chr9:72509783-72555654 (-)
SPRET/EiJ ENSMSPG00010003650
 protein coding gene Chr9:73652086-73690744 (-)
WSB/EiJ ENSIUOG00005023234
 protein coding gene Chr9:72022779-72068968 (-)



Homology
more
  • Human Ortholog
    TMOD2, tropomodulin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMOD2, tropomodulin 2
  • Synonyms
    N-TMOD, NTMOD
  • Links
    NCBI Gene ID: 29767
    UniProt: Q9NZR1

  • Chr Location
    15q21.2; chr15:51751564-51816363 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in enhanced LTP, hyperactivity, impaired startle response, and impaired learning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    685
  • Tissues
    56
  • cDNA Data
    13
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032186 Ensembl Gene Model | MGI Sequence Detail 45705 C57BL/6J ±  kb
    transcript ENSMUST00000215036 Ensembl | MGI Sequence Detail 1797 Not Applicable  
    polypeptide ENSMUSP00000150750 Ensembl | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 17
      Primer pair 2
      Other 2
      Antibodies 2

      Microarray probesets 8
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:60558 Cox PR, et al., Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs. Genomics. 2000 Jan 1;63(1):97-107
    • Latest
      J:350480 Mitra A, et al., Tmod2 Is a Regulator of Cocaine Responses through Control of Striatal and Cortical Excitability and Drug-Induced Plasticity. J Neurosci. 2024 May 1;44(18)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory