About   Help   FAQ
Fbxo6 Gene Detail
Summary
  • Symbol
    Fbxo6
  • Name
    F-box protein 6
  • Synonyms
    FBG2, Fbs2, Fbx6b, Fbxo6b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354743
    NCBI Gene: 50762
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr4:148230173-148236592 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 78.67 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354743
 protein coding gene Chr4:148230173-148236597 (-)
129S1/SvImJ ENSMUSG00200045342
 protein coding gene Chr4:139266215-139272696 (-)
A/J ENSMUSG00195030115
 protein coding gene Chr4:140923926-140930351 (-)
AKR/J ENSMUSG00220046527
 protein coding gene Chr4:140504546-140511014 (-)
BALB/cJ ENSMUSG00180042306
 protein coding gene Chr4:138606590-138613015 (-)
C3H/HeJ ENSMUSG00175036302
 protein coding gene Chr4:141885056-141891523 (-)
C57BL/6NJ ENSMUSG00215047007
 protein coding gene Chr4:140730227-140736650 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026795
 protein coding gene Chr4:137987814-137994926 (-)
CAST/EiJ ENSTCUG00005026792
 protein coding gene Chr4:144559124-144565588 (-)
CBA/J ENSMUSG00210025963
 protein coding gene Chr4:140536741-140543209 (-)
DBA/2J ENSMUSG00185016478
 protein coding gene Chr4:144094894-144101354 (-)
FVB/NJ ENSMUSG00205022678
 protein coding gene Chr4:138999786-139006211 (-)
JF1/MsJ ENSUMUG00000004022
 protein coding gene Chr4:147123124-147129594 (-)
LP/J ENSMUSG00230015715
 protein coding gene Chr4:150837796-150844278 (-)
NOD/ShiLtJ ENSMUSG00190021055
 protein coding gene Chr4:140203326-140209791 (-)
NZO/HlLtJ ENSMUSG00225024401
 protein coding gene Chr4:154829698-154836141 (-)
PWK/PhJ ENSLUMG00010041152
 protein coding gene Chr4:139393024-139399490 (-)
SPRET/EiJ ENSMSPG00010027417
 protein coding gene Chr4:141332398-141338990 (-)
WSB/EiJ ENSIUOG00005043438
 protein coding gene Chr4:138373800-138380289 (-)



Homology
more
  • Human Ortholog
    FBXO6, F-box protein 6
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXO6, F-box protein 6
  • Synonyms
    FBG2, FBS2, FBX6, Fbx6b
  • Links
    NCBI Gene ID: 26270
    UniProt: Q9NRD1

  • Chr Location
    1p36.22; chr1:11664189-11674354 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from multigenic genotypes
    11 phenotype references
Mice homozygous for a null allele exhibit normal development and breeding.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    614
  • Tissues
    14
  • cDNA Data
    74
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 50762 NCBI Gene Model | MGI Sequence Detail 6420 C57BL/6J ±  kb
transcript NM_015797 RefSeq | MGI Sequence Detail 1955 ZRU/MplStud  
polypeptide Q9QZN4 UniProt | EBI | MGI Sequence Detail 295 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 74
    cDNA 74

    Microarray probesets 5
Other
Accession IDs
less
MGI:2140136
References
more
  • Summaries
    All 44
    Developmental Gene Expression 1
    Gene Ontology 11
    Phenotypes 11
  • Earliest
    J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory