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Usp21 Gene Detail
Summary
  • Symbol
    Usp21
  • Name
    ubiquitin specific peptidase 21
  • Synonyms
    ESTM28, Usp16, Usp23, W53272
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353665
    NCBI Gene: 30941
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:171109523-171115534 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 79.30 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    159 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353665
 protein coding gene Chr1:171109519-171115564 (-)
129S1/SvImJ ENSMUSG00200046400
 protein coding gene Chr1:168595324-168601374 (-)
A/J ENSMUSG00195048153
 protein coding gene Chr1:167948654-167954715 (-)
AKR/J ENSMUSG00220026452
 protein coding gene Chr1:167693452-167699497 (-)
BALB/cJ ENSMUSG00180044153
 protein coding gene Chr1:168235582-168241632 (-)
C3H/HeJ ENSMUSG00175041225
 protein coding gene Chr1:168246675-168252725 (-)
C57BL/6NJ ENSMUSG00215044129
 protein coding gene Chr1:168066319-168072365 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014863
 protein coding gene Chr1:161543934-161549915 (-)
CAST/EiJ ENSTCUG00005043273
 protein coding gene Chr1:166580503-166586560 (-)
CBA/J ENSMUSG00210034269
 protein coding gene Chr1:168123604-168129655 (-)
DBA/2J ENSMUSG00185027439
 protein coding gene Chr1:172437554-172443605 (-)
FVB/NJ ENSMUSG00205034083
 protein coding gene Chr1:167132687-167138744 (-)
JF1/MsJ ENSUMUG00000006402
 protein coding gene Chr1:171563135-171569195 (-)
LP/J ENSMUSG00230025066
 protein coding gene Chr1:172012446-172018496 (-)
NOD/ShiLtJ ENSMUSG00190031792
 protein coding gene Chr1:167918096-167924140 (-)
NZO/HlLtJ ENSMUSG00225003909
 protein coding gene Chr1:175632208-175638266 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010045315
 protein coding gene Chr1:170446195-170452252 (-)
WSB/EiJ ENSIUOG00005037267
 protein coding gene Chr1:167332732-167338777 (-)



Homology
more
  • Human Ortholog
    USP21, ubiquitin specific peptidase 21
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP21, ubiquitin specific peptidase 21
  • Synonyms
    USP16, USP23
  • Links
    NCBI Gene ID: 27005
    UniProt: Q9UK80

  • Chr Location
    1q23.3; chr1:161159450-161165723 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable and fertile but develop splenomegaly, show an increased percentage of macrophages and neutrophils in spleen, and are more resistant to vesicular stomatitis virus (VSV) infection with elevated interferon production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    626
  • Tissues
    4
  • cDNA Data
    76
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30941 NCBI Gene Model | MGI Sequence Detail 6012 C57BL/6J ±  kb
    transcript NM_013919 RefSeq | MGI Sequence Detail 2200 ZRU/MplStud  
    polypeptide Q9QZL6 UniProt | EBI | MGI Sequence Detail 566 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000017160 ubiquitin carboxyl-terminal hydrolase 21
      (term hierarchy)
    • EC
      3.4.19.12
    • InterPro Domains
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
      IPR050185 Ubiquitin carboxyl-terminal hydrolase
      IPR018200 Ubiquitin specific protease, conserved site
      IPR028889 Ubiquitin specific protease USP, catalytic domain
    Molecular
    Reagents
    less
    • All nucleic 81
      Genomic 2
      cDNA 76
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1334424
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 23
    • Earliest
      J:52606 Eddleston J, et al., Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics. 1999 Mar 1;56(2):149-59
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory