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Gulo Gene Detail
Summary
  • Symbol
    Gulo
  • Name
    gulonolactone (L-) oxidase
  • Synonyms
    L-gulono-gamma-lactone oxidase, MGC:29968, MGC:37793, MGC:37880, sfx
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353434
    NCBI Gene: 268756
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:66224235-66246656 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.36 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    871 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353434
 protein coding gene Chr14:66224235-66246703 (-)
129S1/SvImJ ENSMUSG00200028293
 protein coding gene Chr14:54824760-54847156 (-)
A/J ENSMUSG00195013039
 protein coding gene Chr14:55002087-55024495 (-)
AKR/J ENSMUSG00220031949
 protein coding gene Chr14:54342596-54365006 (-)
BALB/cJ ENSMUSG00180031755
 protein coding gene Chr14:54618277-54640690 (-)
C3H/HeJ ENSMUSG00175034184
 protein coding gene Chr14:56361174-56383575 (-)
C57BL/6NJ ENSMUSG00215011705
 protein coding gene Chr14:54557196-54579619 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019433
 protein coding gene Chr14:57129951-57152446 (-)
CAST/EiJ ENSTCUG00005035144
 protein coding gene Chr14:56262027-56284336 (-)
CBA/J ENSMUSG00210034222
 protein coding gene Chr14:54989433-55011846 (-)
DBA/2J ENSMUSG00185031258
 protein coding gene Chr14:60159003-60181407 (-)
FVB/NJ ENSMUSG00205029011
 protein coding gene Chr14:54504915-54527328 (-)
JF1/MsJ ENSUMUG00000032548
 protein coding gene Chr14:71331432-71353944 (-)
LP/J ENSMUSG00230035771
 protein coding gene Chr14:72188285-72210692 (-)
NOD/ShiLtJ ENSMUSG00190031622
 protein coding gene Chr14:54784141-54806544 (-)
NZO/HlLtJ ENSMUSG00225039857
 protein coding gene Chr14:62517033-62539439 (-)
PWK/PhJ ENSLUMG00010035057
 protein coding gene Chr14:54222158-54244582 (-)
SPRET/EiJ ENSMSPG00010028357
 protein coding gene Chr14:57713215-57734987 (-)
WSB/EiJ ENSIUOG00005038776
 protein coding gene Chr14:54220762-54243160 (-)



Homology
more
  • Human Ortholog
    GULOP, gulonolactone (L-) oxidase, pseudogene
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GULOP, gulonolactone (L-) oxidase, pseudogene
  • Synonyms
    GULO, SCURVY
  • Links
    NCBI Gene ID: 2989

  • Chr Location
    8p21.1; chr8:27560274-27589073 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 3 alleles in 4 genetic backgrounds
    23 phenotypes from multigenic genotypes
    4 images
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for spontaneous mutations exhibit impaired growth and mobility, decreased spleen and thymus weights, reduced serum calcium, phosphate, alkaline phosphatase, IGF1, and osteocalcin levels, and small, fragile and histologically abnormal bones.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    102
  • cDNA Data
    71
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034450 Ensembl Gene Model | MGI Sequence Detail 22422 C57BL/6J ±  kb
    transcript ENSMUST00000059970 Ensembl | MGI Sequence Detail 2263 Not Applicable  
    polypeptide ENSMUSP00000060912 Ensembl | MGI Sequence Detail 440 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008398 L-gulonolactone oxidase
      (term hierarchy)
    • EC
      1.1.3.8
    • InterPro Domains
      IPR007173 D-arabinono-1,4-lactone oxidase, C-terminal domain
      IPR016166 FAD-binding domain, PCMH-type
      IPR036318 FAD-binding, type PCMH-like superfamily
      IPR016167 FAD-binding, type PCMH, subdomain 1
      IPR016169 FAD-binding, type PCMH, subdomain 2
      IPR006094 FAD linked oxidase, N-terminal
      IPR010031 L-gulonolactone/D-arabinono-1,4-lactone oxidase-like
      IPR006093 Oxygen oxidoreductase covalent FAD-binding site
      IPR030654 Sugar 1,4-lactone oxidase
      IPR016171 Vanillyl-alcohol oxidase, C-terminal subdomain 2
    • GlyGen
      P58710 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 71
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1890379, MGI:2145730, MGI:2679273
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 64
    • Earliest
      J:59058 Braun L, et al., Different induction of gulonolactone oxidase in aromatic hydrocarbon-responsive or -unresponsive mouse strains. FEBS Lett. 1999 Dec 17;463(3):345-9
    • Latest
      J:365117 Comazzetto S, et al., Ascorbate deficiency increases quiescence and self-renewal in hematopoietic stem cells and multipotent progenitors. Blood. 2025 Jan 2;145(1):114-126
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/08/2026
    MGI 6.24     		The Jackson Laboratory