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Opn4 Gene Detail
Summary
  • Symbol
    Opn4
  • Name
    opsin 4 (melanopsin)
  • Synonyms
    1110007J02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353425
    NCBI Gene: 30044
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:34312575-34322099 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 20.83 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    390 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353425
 protein coding gene Chr14:34312575-34322099 (-)
129S1/SvImJ ENSMUSG00200036711
 protein coding gene Chr14:26158210-26167718 (-)
A/J ENSMUSG00195013212
 protein coding gene Chr14:27213552-27223077 (-)
AKR/J ENSMUSG00220034034
 protein coding gene Chr14:26332318-26341843 (-)
BALB/cJ ENSMUSG00180028140
 protein coding gene Chr14:26302028-26311554 (-)
C3H/HeJ ENSMUSG00175037184
 protein coding gene Chr14:26369111-26378635 (-)
C57BL/6NJ ENSMUSG00215020699
 protein coding gene Chr14:26605842-26615366 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019124
 protein coding gene Chr14:26892029-26901791 (-)
CAST/EiJ ENSTCUG00005021436
 protein coding gene Chr14:26443868-26453372 (-)
CBA/J ENSMUSG00210038058
 protein coding gene Chr14:26616258-26625782 (-)
DBA/2J ENSMUSG00185014501
 protein coding gene Chr14:30878028-30887553 (-)
FVB/NJ ENSMUSG00205015988
 protein coding gene Chr14:26473849-26483373 (-)
JF1/MsJ ENSUMUG00000047010
 protein coding gene Chr14:38148599-38158106 (-)
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190017531
 protein coding gene Chr14:26620757-26630281 (-)
NZO/HlLtJ ENSMUSG00225041585
 protein coding gene Chr14:32500619-32510143 (-)
PWK/PhJ ENSLUMG00010022058
 protein coding gene Chr14:14734950-14744479 (-)
SPRET/EiJ ENSMSPG00010037464
 protein coding gene Chr14:28304833-28314344 (-)
WSB/EiJ ENSIUOG00005011718
 protein coding gene Chr14:26445071-26454612 (-)



Homology
more
  • Human Ortholog
    OPN4, opsin 4
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OPN4, opsin 4
  • Synonyms
    MOP
  • Links
    NCBI Gene ID: 94233
    UniProt: Q9UHM6

  • Chr Location
    10q23.2; chr10:86654518-86666460 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 5 genetic backgrounds
    18 phenotypes from multigenic genotypes
    196 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in absent intrinsic inner retinal photosensitivity, abnormal pupillary reflex, and abnormal circadian rhythms.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    651
  • Tissues
    26
  • cDNA Data
    8
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30044 NCBI Gene Model | MGI Sequence Detail 9525 C57BL/6J ±  kb
    transcript NM_001128599 RefSeq | MGI Sequence Detail 2259 Not Specified  
    polypeptide Q9QXZ9 UniProt | EBI | MGI Sequence Detail 521 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 8
      Primer pair 2
      Other 1
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2685379
    References
    more
    • Summaries
      All 264
      Developmental Gene Expression 24
      Gene Ontology 21
      Phenotypes 196
    • Earliest
      J:59329 Provencio I, et al., A novel human opsin in the inner retina. J Neurosci. 2000 Jan 15;20(2):600-5
    • Latest
      J:390366 Daly KM, et al., M4-ipRGCs regulate contrast sensitivity in vision. Cell Rep. 2026 Jul 5;45(7):117662
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory