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Pdxk Gene Detail
Summary
  • Symbol
    Pdxk
  • Name
    pyridoxal (pyridoxine, vitamin B6) kinase
  • Synonyms
    2310036D04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351869
    NCBI Gene: 216134
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:78272581-78300782 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    861 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351869
 protein coding gene Chr10:78272578-78300809 (-)
129S1/SvImJ ENSMUSG00200044910
 protein coding gene Chr10:74950704-74978938 (-)
A/J ENSMUSG00195042119
 protein coding gene Chr10:75287380-75315618 (-)
AKR/J ENSMUSG00220046320
 protein coding gene Chr10:74947065-74975301 (-)
BALB/cJ ENSMUSG00180051767
 protein coding gene Chr10:75301756-75329986 (-)
C3H/HeJ ENSMUSG00175051221
 protein coding gene Chr10:75172865-75201097 (-)
C57BL/6NJ ENSMUSG00215051035
 protein coding gene Chr10:74910629-74938864 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015510
 protein coding gene Chr10:72487952-72517180 (-)
CAST/EiJ ENSTCUG00005046778
 protein coding gene Chr10:74786132-74814472 (-)
CBA/J ENSMUSG00210036968
 protein coding gene Chr10:75028993-75057224 (-)
DBA/2J ENSMUSG00185047590
 protein coding gene Chr10:75371346-75399583 (-)
FVB/NJ ENSMUSG00205049076
 protein coding gene Chr10:75063370-75091609 (-)
JF1/MsJ ENSUMUG00000017112
 protein coding gene Chr10:76531866-76560129 (-)
LP/J ENSMUSG00230050211
 protein coding gene Chr10:77140818-77169052 (-)
NOD/ShiLtJ ENSMUSG00190049072
 protein coding gene Chr10:75348766-75376999 (-)
NZO/HlLtJ ENSMUSG00225045929
 protein coding gene Chr10:81427725-81455935 (-)
PWK/PhJ ENSLUMG00010050479
 protein coding gene Chr10:74914063-74942300 (-)
SPRET/EiJ ENSMSPG00010047077
 protein coding gene Chr10:76698394-76723555 (-)
WSB/EiJ ENSIUOG00005051150
 protein coding gene Chr10:74947823-74976464 (-)



Homology
more
  • Human Ortholog
    PDXK, pyridoxal kinase
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDXK, pyridoxal kinase
  • Synonyms
    C21orf124, C21orf97, HEL-S-1a, HMSN6C, PKH, PNK, PRED79
  • Links
    NCBI Gene ID: 8566
    UniProt: O00764

  • Chr Location
    21q22.3; chr21:43719094-43762307 (+)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    6
  • Gene trapped
    1
  • Targeted
    6
  • Genomic Mutations
    3 involving Pdxk
  • Find Mice (IMSR)
    30 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    985
  • Tissues
    185
  • cDNA Data
    19
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 216134 NCBI Gene Model | MGI Sequence Detail 28202 C57BL/6J ±  kb
transcript NM_172134 RefSeq | MGI Sequence Detail 5110 FVB/N  
polypeptide Q8K183 UniProt | EBI | MGI Sequence Detail 312 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    Genomic 11
    cDNA 20
    Primer pair 1
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1916848, MGI:2143917, MGI:3034915
References
more
  • Summaries
    All 88
    Developmental Gene Expression 6
    Diseases 2
    Gene Ontology 14
    Phenotypes 43
  • Earliest
    J:336443 Hamfelt A, Pyridoxal kinase activity in blood cells. Clin Chim Acta. 1967 Apr;16(1):7-18
  • Latest
    J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory