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Abcf1 Gene Detail
Summary
  • Symbol
    Abcf1
  • Name
    ATP-binding cassette, sub-family F member 1
  • Synonyms
    Abc50, D17Wsu166e, GCN20
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351658
    NCBI Gene: 224742
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:36267711-36280642 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.80 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351658
 protein coding gene Chr17:36267711-36280653 (-)
129S1/SvImJ ENSMUSG00200050070
 protein coding gene Chr17:31893027-31905970 (-)
A/J ENSMUSG00195043481
 protein coding gene Chr17:32955069-32968002 (-)
AKR/J ENSMUSG00220050580
 protein coding gene Chr17:31756345-31769580 (-)
BALB/cJ ENSMUSG00180033975
 protein coding gene Chr17:32324636-32337472 (-)
C3H/HeJ ENSMUSG00175026962
 protein coding gene Chr17:31642182-31655416 (-)
C57BL/6NJ ENSMUSG00215050254
 protein coding gene Chr17:31718284-31731225 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021545
 protein coding gene Chr17:33035747-33048420 (-)
CAST/EiJ ENSTCUG00005048251
 protein coding gene Chr17:32784532-32797372 (-)
CBA/J ENSMUSG00210042325
 protein coding gene Chr17:31464237-31477451 (-)
DBA/2J ENSMUSG00185050093
 protein coding gene Chr17:34343783-34356622 (-)
FVB/NJ ENSMUSG00205029206
 protein coding gene Chr17:32011267-32024200 (-)
JF1/MsJ ENSUMUG00000037210
 protein coding gene Chr17:33300344-33313258 (-)
LP/J ENSMUSG00230053156
 protein coding gene Chr17:35381701-35394644 (-)
NOD/ShiLtJ ENSMUSG00190051817
 protein coding gene Chr17:31630375-31643308 (-)
NZO/HlLtJ ENSMUSG00225054809
 protein coding gene Chr17:37468172-37481406 (-)
PWK/PhJ ENSLUMG00010041580
 protein coding gene Chr17:31263084-31275971 (-)
SPRET/EiJ ENSMSPG00010049745
 protein coding gene Chr17:32472103-32487080 (-)
WSB/EiJ ENSIUOG00005044264
 protein coding gene Chr17:32447203-32460037 (-)



Homology
more
  • Human Ortholog
    ABCF1, ATP binding cassette subfamily F member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABCF1, ATP binding cassette subfamily F member 1
  • Synonyms
    ABC27, ABC50
  • Links
    NCBI Gene ID: 23
    UniProt: Q8NE71

  • Chr Location
    6p21.33; chr6:30571393-30597179 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display lethality shortly after implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    667
  • Tissues
    56
  • cDNA Data
    245
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 224742 NCBI Gene Model | MGI Sequence Detail 12932 C57BL/6J ±  kb
    transcript NM_013854 RefSeq | MGI Sequence Detail 3207 Not Specified  
    polypeptide Q6P542 UniProt | EBI | MGI Sequence Detail 837 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000003569 ATP-binding cassette sub-family F member 1
      (term hierarchy)
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR050611 ABCF protein
      IPR003439 ABC transporter-like, ATP-binding domain
      IPR017871 ABC transporter-like, conserved site
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q6P542 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 247
      cDNA 245
      Primer pair 1
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-36426, MGI:107849, MGI:2147001
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory