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Atic Gene Detail
Summary
  • Symbol
    Atic
  • Name
    5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
  • Synonyms
    2610509C24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351352
    NCBI Gene: 108147
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:71596315-71618562 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 36.03 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    868 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351352
 protein coding gene Chr1:71596309-71618790 (+)
129S1/SvImJ ENSMUSG00200004762
 protein coding gene Chr1:69254355-69276837 (+)
A/J ENSMUSG00195029388
 protein coding gene Chr1:68668812-68691294 (+)
AKR/J ENSMUSG00220035367
 protein coding gene Chr1:68821262-68843719 (+)
BALB/cJ ENSMUSG00180029626
 protein coding gene Chr1:68936652-68959131 (+)
C3H/HeJ ENSMUSG00175000766
 protein coding gene Chr1:69064252-69086734 (+)
C57BL/6NJ ENSMUSG00215015801
 protein coding gene Chr1:68982522-69005004 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014238
 protein coding gene Chr1:65161410-65183780 (+)
CAST/EiJ ENSTCUG00005019982
 protein coding gene Chr1:68722153-68764200 (+)
CBA/J ENSMUSG00210003117
 protein coding gene Chr1:68764698-68787180 (+)
DBA/2J ENSMUSG00185004821
 protein coding gene Chr1:69855281-69877764 (+)
FVB/NJ ENSMUSG00205011790
 protein coding gene Chr1:68503037-68525517 (+)
JF1/MsJ ENSUMUG00000003085
 protein coding gene Chr1:68737769-68760376 (+)
LP/J ENSMUSG00230002386
 protein coding gene Chr1:69849547-69872030 (+)
NOD/ShiLtJ ENSMUSG00190012883
 protein coding gene Chr1:68981634-69004116 (+)
NZO/HlLtJ ENSMUSG00225039165
 protein coding gene Chr1:73064620-73087101 (+)
PWK/PhJ ENSLUMG00010007477
 protein coding gene Chr1:68349864-68372478 (+)
SPRET/EiJ ENSMSPG00010017779
 protein coding gene Chr1:70441647-70463353 (+)
WSB/EiJ ENSIUOG00005026885
 protein coding gene Chr1:68602078-68624536 (+)



Homology
more
  • Human Ortholog
    ATIC, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATIC, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
  • Synonyms
    AICAR, AICARFT, HEL-S-70p, IMPCHASE, PURH
  • Links
    NCBI Gene ID: 471
    UniProt: P31939

  • Chr Location
    2q35; chr2:215311956-215368592 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ATIC associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    129
  • cDNA Data
    119
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 108147 NCBI Gene Model | MGI Sequence Detail 22248 C57BL/6J ±  kb
transcript NM_026195 RefSeq | MGI Sequence Detail 2611 C57BL/6  
polypeptide Q9CWJ9 UniProt | EBI | MGI Sequence Detail 592 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 125
    cDNA 123
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGI:1914741, MGI:2138111, MGI:2138576
References
more
  • Summaries
    All 58
    Developmental Gene Expression 6
    Gene Ontology 17
    Phenotypes 13
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:384974 Ma Q, et al., Purine metabolic adaptation protects the endothelium from disturbed flow-induced DNA damage and atherosclerosis. Proc Natl Acad Sci U S A. 2026 May 5;123(18):e2526299123
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory