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Exo1 Gene Detail
Summary
  • Symbol
    Exo1
  • Name
    exonuclease 1
  • Synonyms
    5730442G03Rik, Msa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349427
    NCBI Gene: 26909
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:175708334-175738962 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 81.90 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1107 from dbSNP Build 142
  • Strain Annotations
    15
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349427
 protein coding gene Chr1:175708147-175741055 (+)
129S1/SvImJ ENSMUSGG00200054654
 protein coding gene Chr1:173466313-173475506 (+)
A/J ENSMUSGG00195055184
 protein coding gene Chr1:172883146-172892334 (+)
AKR/J ENSMUSGG00220054438
 protein coding gene Chr1:172473622-172482810 (+)
BALB/cJ ENSMUSGG00180055221
 protein coding gene Chr1:173117231-173126424 (+)
C3H/HeJ ENSMUSGG00175054615
 protein coding gene Chr1:173293404-173302597 (+)
C57BL/6NJ ENSMUSGG00215055366
 protein coding gene Chr1:172671590-172680777 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014948
 protein coding gene Chr1:165960999-165991630 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054715
 protein coding gene Chr1:172929108-172938296 (+)
DBA/2J ENSMUSGG00185057449
 protein coding gene Chr1:177547833-177557020 (+)
FVB/NJ ENSMUSGG00205054102
 protein coding gene Chr1:172041070-172050258 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055465
 protein coding gene Chr1:177132456-177141649 (+)
NOD/ShiLtJ ENSMUSGG00190054606
 protein coding gene Chr1:172967955-172977148 (+)
NZO/HlLtJ ENSMUSG00225004140
 protein coding gene Chr1:180699158-180730570 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010029602
 protein coding gene Chr1:175301647-175332526 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    EXO1, exonuclease 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EXO1, exonuclease 1
  • Synonyms
    HEX1, hExoI
  • Links
    NCBI Gene ID: 9156
    UniProt: Q9UQ84

  • Chr Location
    1q43; chr1:241847967-241895148 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 3 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    3 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in reduced life span, lymphoma development, and male/female sterilty due to defective meiosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1149
  • Tissues
    175
  • cDNA Data
    66
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26909 NCBI Gene Model | MGI Sequence Detail 30629 C57BL/6J ±  kb
    transcript NM_012012 RefSeq | MGI Sequence Detail 7585 C57BL/6  
    polypeptide Q9QZ11 UniProt | EBI | MGI Sequence Detail 837 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      cDNA 66
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917804
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 30
    • Earliest
      J:58084 Lee BI, et al., Expression specificity of the mouse exonuclease 1 (mExo1) gene. Nucleic Acids Res. 1999 Oct 15;27(20):4114-20
    • Latest
      J:367761 Kim S, et al., Mouse MRE11-RAD50-NBS1 is needed to start and extend meiotic DNA end resection. Nat Commun. 2025 Apr 16;16(1):3613
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory