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Racgap1 Gene Detail
Summary
  • Symbol
    Racgap1
  • Name
    Rac GTPase-activating protein 1
  • Synonyms
    Band25, gtl11, GTPase, MgcRacGAP, mKIAA1478
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349423
    NCBI Gene: 26934
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:99518377-99549504 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.13 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    861 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349423
 protein coding gene Chr15:99518377-99549537 (-)
129S1/SvImJ ENSMUSG00200048700
 protein coding gene Chr15:96721316-96752485 (-)
A/J ENSMUSG00195039048
 protein coding gene Chr15:96588079-96619253 (-)
AKR/J ENSMUSG00220047466
 protein coding gene Chr15:96594901-96626065 (-)
BALB/cJ ENSMUSG00180042972
 protein coding gene Chr15:96496259-96527404 (-)
C3H/HeJ ENSMUSG00175038892
 protein coding gene Chr15:96768082-96799256 (-)
C57BL/6NJ ENSMUSG00215048768
 protein coding gene Chr15:96556771-96587946 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020272
 protein coding gene Chr15:93329070-93359589 (-)
CAST/EiJ ENSTCUG00005044576
 protein coding gene Chr15:96039309-96069417 (-)
CBA/J ENSMUSG00210030454
 protein coding gene Chr15:96553211-96584350 (-)
DBA/2J ENSMUSG00185039174
 protein coding gene Chr15:96601307-96632471 (-)
FVB/NJ ENSMUSG00205037407
 protein coding gene Chr15:96305763-96336926 (-)
JF1/MsJ ENSUMUG00000043460
 protein coding gene Chr15:96056442-96086394 (-)
LP/J ENSMUSG00230037730
 protein coding gene Chr15:99944693-99975856 (-)
NOD/ShiLtJ ENSMUSG00190039457
 protein coding gene Chr15:96571533-96602711 (-)
NZO/HlLtJ ENSMUSG00225042337
 protein coding gene Chr15:100193649-100224810 (-)
PWK/PhJ ENSLUMG00010045695
 protein coding gene Chr15:96276375-96307543 (-)
SPRET/EiJ ENSMSPG00010046879
 protein coding gene Chr15:98080656-98112174 (-)
WSB/EiJ ENSIUOG00005036620
 protein coding gene Chr15:96681923-96713019 (-)



Homology
more
  • Human Ortholog
    RACGAP1, Rac GTPase activating protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RACGAP1, Rac GTPase activating protein 1
  • Synonyms
    CDAN3B, CYK4, HsCYK-4, ID-GAP, MgcRacGAP, RCGAP1
  • Links
    NCBI Gene ID: 29127
    UniProt: Q9H0H5

  • Chr Location
    12q13.12; chr12:49976923-50033440 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RACGAP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 3 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a gene-trapped allele exhibit pre-implantation lethality associated with the formation of multinucleated blastomeres and failure to complete cytokinesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    91
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    73
  • cDNA Data
    159
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26934 NCBI Gene Model | MGI Sequence Detail 31128 C57BL/6J ±  kb
    transcript NM_012025 RefSeq | MGI Sequence Detail 3032 C57BL/6  
    polypeptide Q9WVM1 UniProt | EBI | MGI Sequence Detail 628 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000013663 Rac GTPase-activating protein 1
      (term hierarchy)
    • InterPro Domains
      IPR046349 C1-like domain superfamily
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
      IPR000198 Rho GTPase-activating protein domain
      IPR008936 Rho GTPase activation protein
    • GlyGen
      Q9WVM1 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 162
      cDNA 160
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145962, MGI:2145986
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 9
      Phenotypes 34
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory