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Foxk1 Gene Detail
Summary
  • Symbol
    Foxk1
  • Name
    forkhead box K1
  • Synonyms
    A630048H08Rik, Mnf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347488
    NCBI Gene: 17425
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:142387252-142447766 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 81.53 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1610 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347488
 protein coding gene Chr5:142387252-142447770 (+)
129S1/SvImJ ENSMUSG00200040959
 protein coding gene Chr5:136257281-136318002 (+)
A/J ENSMUSG00195039892
 protein coding gene Chr5:135892657-135958929 (+)
AKR/J ENSMUSG00220021204
 protein coding gene Chr5:135134615-135195341 (+)
BALB/cJ ENSMUSG00180031490
 protein coding gene Chr5:135994769-136061025 (+)
C3H/HeJ ENSMUSG00175044520
 protein coding gene Chr5:137920404-137986666 (+)
C57BL/6NJ ENSMUSG00215033123
 protein coding gene Chr5:135834432-135895144 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027959
 protein coding gene Chr5:135128726-135192555 (+)
CAST/EiJ ENSTCUG00005035285
 protein coding gene Chr5:135275370-135338724 (+)
CBA/J ENSMUSG00210022727
 protein coding gene Chr5:136726919-136787902 (+)
DBA/2J ENSMUSG00185051324
 protein coding gene Chr5:139734062-139794788 (+)
FVB/NJ ENSMUSG00205027930
 protein coding gene Chr5:135556613-135617325 (+)
JF1/MsJ ENSUMUG00000045555
 protein coding gene Chr5:142604719-142665319 (+)
LP/J ENSMUSG00230022770
 protein coding gene Chr5:143861100-143921821 (+)
NOD/ShiLtJ ENSMUSG00190031590
 protein coding gene Chr5:135690096-135750808 (+)
NZO/HlLtJ ENSMUSG00225022234
 protein coding gene Chr5:151329974-151390679 (+)
PWK/PhJ ENSLUMG00010018516
 protein coding gene Chr5:134318736-134379415 (+)
SPRET/EiJ ENSMSPG00010024485
 protein coding gene Chr5:137929958-137993800 (+)
WSB/EiJ ENSIUOG00005035192
 protein coding gene Chr5:138218939-138279649 (+)



Homology
more
  • Human Ortholog
    FOXK1, forkhead box K1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXK1, forkhead box K1
  • Synonyms
    FOXK1L
  • Links
    NCBI Gene ID: 221937
    UniProt: P85037

  • Chr Location
    7p22.1; chr7:4682295-4771442 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    13 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are runted and exhibit a reduced myogenic progenitor cell population with impaired cell cycle progression (G0/G1 arrest) and decreased proliferative capacity that results in severe impairment of skeletal muscle regeneration following injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    795
  • Tissues
    137
  • cDNA Data
    17
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056493 Ensembl Gene Model | MGI Sequence Detail 60515 C57BL/6J ±  kb
    transcript ENSMUST00000072837 Ensembl | MGI Sequence Detail 7439 Not Applicable  
    polypeptide ENSMUSP00000072616 Ensembl | MGI Sequence Detail 719 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 18
      Primer pair 6
      Other 2
      Antibodies 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12338, MGI:2140907, MGI:97042
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 14
      Phenotypes 12
    • Earliest
      J:18888 Bassel-Duby R, et al., Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. Mol Cell Biol. 1994 Jul;14(7):4596-605
    • Latest
      J:381217 Xiang Y, et al., Counteracting FOX proteins epigenetically control the herpesvirus lytic-latent balance. Nat Commun. 2026 Feb 2;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory