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Trip6 Gene Detail
Summary
  • Symbol
    Trip6
  • Name
    thyroid hormone receptor interactor 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343458
    NCBI Gene: 22051
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137308160-137312469 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    182 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343458
 protein coding gene Chr5:137307916-137312666 (-)
129S1/SvImJ ENSMUSG00200041394
 protein coding gene Chr5:131102336-131107076 (-)
A/J ENSMUSG00195045524
 protein coding gene Chr5:130605031-130609771 (-)
AKR/J ENSMUSG00220048134
 protein coding gene Chr5:130080354-130085102 (-)
BALB/cJ ENSMUSG00180037121
 protein coding gene Chr5:130701596-130706336 (-)
C3H/HeJ ENSMUSG00175045201
 protein coding gene Chr5:132629142-132633882 (-)
C57BL/6NJ ENSMUSG00215047692
 protein coding gene Chr5:130750980-130755726 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027871
 protein coding gene Chr5:130115459-130120180 (-)
CAST/EiJ ENSTCUG00005009542
 protein coding gene Chr5:129972427-129977134 (-)
CBA/J ENSMUSG00210006543
 protein coding gene Chr5:131446712-131451452 (-)
DBA/2J ENSMUSG00185054137
 protein coding gene Chr5:134462101-134466841 (-)
FVB/NJ ENSMUSG00205029770
 protein coding gene Chr5:130346541-130351281 (-)
JF1/MsJ ENSUMUG00000023885
 protein coding gene Chr5:137352444-137357175 (-)
LP/J ENSMUSG00230044124
 protein coding gene Chr5:138575581-138580321 (-)
NOD/ShiLtJ ENSMUSG00190027095
 protein coding gene Chr5:130401390-130406130 (-)
NZO/HlLtJ ENSMUSG00225023301
 protein coding gene Chr5:146250853-146255593 (-)
PWK/PhJ ENSLUMG00010016013
 protein coding gene Chr5:129208907-129213648 (-)
SPRET/EiJ ENSMSPG00010036099
 protein coding gene Chr5:132611552-132616341 (-)
WSB/EiJ ENSIUOG00005034085
 protein coding gene Chr5:133052383-133057131 (-)



Homology
more
  • Human Ortholog
    TRIP6, thyroid hormone receptor interactor 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIP6, thyroid hormone receptor interactor 6
  • Synonyms
    OIP-1, OIP1, TRIP-6, TRIP6i2, ZRP-1
  • Links
    NCBI Gene ID: 7205
    UniProt: Q15654

  • Chr Location
    7q22.1; chr7:100867126-100873524 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit poorly differentiated brain ependymal and choroid plexus epithelial cells with fewer and shorter cilia and develop hydrocephalus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    739
  • Tissues
    119
  • cDNA Data
    90
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22051 NCBI Gene Model | MGI Sequence Detail 4310 C57BL/6J ±  kb
    transcript NR_184539 RefSeq | MGI Sequence Detail 1779 C57BL/6  
    polypeptide Q9Z1Y4 UniProt | EBI | MGI Sequence Detail 480 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 93
      cDNA 90
      Primer pair 3
      Antibodies 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 12
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:56267 Wang Y, et al., Characterization of mouse Trip6: a putative intracellular signaling protein. Gene. 1999 Jul 8;234(2):403-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory