About   Help   FAQ
Ikzf2 Gene Detail
Summary
  • Symbol
    Ikzf2
  • Name
    IKAROS family zinc finger 2
  • Synonyms
    A730095J18Rik, Helios, Zfpn1a2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342541
    NCBI Gene: 22779
  • Alliance
    genome feature page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:69570373-69726404 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 34.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4252 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342541
 protein coding gene Chr1:69570373-69726510 (-)
129S1/SvImJ ENSMUSG00200004346
 protein coding gene Chr1:67224124-67380147 (-)
A/J ENSMUSG00195029193
 protein coding gene Chr1:66647199-66803295 (-)
AKR/J ENSMUSG00220036803
 protein coding gene Chr1:66815757-66970337 (-)
BALB/cJ ENSMUSG00180030078
 protein coding gene Chr1:66906377-67062434 (-)
C3H/HeJ ENSMUSG00175000762
 protein coding gene Chr1:67033686-67189739 (-)
C57BL/6NJ ENSMUSG00215012586
 protein coding gene Chr1:66944787-67100829 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014233
 protein coding gene Chr1:63188994-63342230 (-)
CAST/EiJ ENSTCUG00005020800
 protein coding gene Chr1:66688800-66849098 (-)
CBA/J ENSMUSG00210003150
 protein coding gene Chr1:66734461-66890483 (-)
DBA/2J ENSMUSG00185005088
 protein coding gene Chr1:67825017-67981041 (-)
FVB/NJ ENSMUSG00205014539
 protein coding gene Chr1:66490181-66646226 (-)
JF1/MsJ ENSUMUG00000001721
 protein coding gene Chr1:66731540-66891236 (-)
LP/J ENSMUSG00230002495
 protein coding gene Chr1:67819390-67975405 (-)
NOD/ShiLtJ ENSMUSG00190012378
 protein coding gene Chr1:66942402-67098463 (-)
NZO/HlLtJ ENSMUSG00225000974
 protein coding gene Chr1:71034457-71190490 (-)
PWK/PhJ ENSLUMG00010007268
 protein coding gene Chr1:66236106-66397235 (-)
SPRET/EiJ ENSMSPG00010017234
 protein coding gene Chr1:68350463-68504835 (-)
WSB/EiJ ENSIUOG00005028511
 protein coding gene Chr1:66544974-66699604 (-)



Homology
more
  • Human Ortholog
    IKZF2, IKAROS family zinc finger 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IKZF2, IKAROS family zinc finger 2
  • Synonyms
    ANF1A2, HELIOS, ICHAD, IMDIA, ZNF1A2, ZNFN1A2
  • Links
    NCBI Gene ID: 22807
    UniProt: Q9UKS7

  • Chr Location
    2q34; chr2:212999691-213152456 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 4 alleles in 5 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit postnatal lethality for unknown reasons. Survivors have decreased body weight. Postnatal lethality has complete penetrance on the C57BL/6 strain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    78
  • cDNA Data
    39
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025997 Ensembl Gene Model | MGI Sequence Detail 156032 C57BL/6J ±  kb
    transcript ENSMUST00000190771 Ensembl | MGI Sequence Detail 2483 Not Applicable  
    polypeptide ENSMUSP00000139543 Ensembl | MGI Sequence Detail 532 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 39
      Primer pair 2
      Other 1
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1276117, MGI:2442076
    References
    more
    • Summaries
      All 110
      Developmental Gene Expression 14
      Gene Ontology 6
      Phenotypes 40
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:379396 Xie X, et al., Eos plays a critical role in Treg homeostasis and modulates the function of recirculating thymic Tregs in the control of Treg development. Cell Rep. 2026 Jan 27;45(1):116838
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory